makatoxin I (BMK I)

a nitrergically active toxin from the scorpion Buthus martensi Karsch; amino acid sequence in first source
Also Known As:
BMK I; MkTx 1
Networked: 13 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results


1. Ji, Yong-Hua: 11 articles (06/2015 - 10/2003)
2. Jiang, Feng: 5 articles (06/2015 - 11/2010)
3. Fu, Jin: 4 articles (06/2015 - 10/2013)
4. Hua, Li-Ming: 4 articles (02/2014 - 11/2010)
5. Jiao, Yun-Lu: 3 articles (06/2015 - 10/2013)
6. Liu, Tong: 3 articles (06/2015 - 01/2006)
7. Zhao, Rong: 3 articles (01/2015 - 12/2005)
8. Feng, Yi-Jun: 2 articles (06/2015 - 01/2015)
9. Tao, Jie: 2 articles (06/2015 - 01/2015)
10. Ji, Yonghua: 2 articles (06/2015 - 10/2010)

Related Diseases

1. Pain (Aches)
2. Epilepsy (Aura)
3. Hypersensitivity (Allergy)
02/01/2014 - "Intrathecal administration of deforolimus, a specific inhibitor of mTOR, attenuated BmK I-induced pain responses (spontaneous flinching, paroxysmal pain-like behavior, and mechanical hypersensitivity). "
10/25/2013 - "The unilateral thermal and bilateral mechanical pain hypersensitivity of rat induced by BmK I was suppressed in a dose-dependent manner following pretreatment with SB203580 (a specific inhibitor of p-p38). "
01/01/2013 - "In addition, intrathecal (i.t.) injection of rapamycin - a specific inhibitor of mTOR - was observed to result in the reduction of spontaneous pain responses and the attenuation of unilateral thermal and bilateral mechanical hypersensitivity elicited by BmK I. Thus, these results indicate that the mTOR signaling pathway is mobilized in the induction and maintenance of pain-activated hypersensitivity. "
06/25/2015 - "Animal behavioral testing, RT-PCR and Western blotting were used to yield the following results: first, intraplantar (i.pl.) injection of BmK I (10 μg) induced elevated mRNA and protein levels of 5-HT3AR in bilateral L4-L5 spinal cord; Second, intrathecal (i.t.) injection of ondansetron (a specific antagonist of 5-HT3AR) reduced spontaneous pain responses, attenuated unilateral thermal and bilateral mechanical hypersensitivity elicited by BmK I; Microglia could be activated by BmK I (i.pl.) in both sides of L4-L5 spinal cord, and this effect was reversed by intrathecal pre-treatment with 5-HT3AR antagonist. "
10/25/2013 - "Intraplantar (i.pl.) injection of BmK I, a receptor site 3-specific modulator of voltage-gated sodium channels (VGSCs) from the venom of scorpion Buthus martensi Karsch (BmK), was shown to induce long-lasting and spontaneous nociceptive responses as demonstrated through experiments utilizing primary thermal and mirror-imaged mechanical hypersensitivity with different time course of development in rats. "
4. Hyperalgesia
5. Tachycardia (Tachyarrhythmias)

Related Drugs and Biologics

1. Sodium Channels (Sodium Channel)
2. Venoms
3. mecarzole (BMK)
4. Scorpion Venoms (Scorpion Venom)
5. Sirolimus (Rapamycin)
6. Ondansetron (Zofran)
7. Tetrodotoxin (Tetradotoxin)
8. Sodium
9. Messenger RNA (mRNA)
10. Morphine (MS Contin)

Related Therapies and Procedures

1. Subcutaneous Injections