endomorphin 2

isolated from bovine brain

Also Known As:

Tyr-Pro-Phe-Phe-NH2; endomorphin-2; l-phenylalaninamide, l-tyrosyl-l-prolyl-l-phenylalanyl-; l-tyrosyl-l-prolyl-l-phenylalanyl-l-phenylalaninamide; l-tyrosyl-l-prolyl-l-phenylalanyl-l-phenylalaninamide, (-)-; tetrapeptide-15; tyrosyl-prolyl-phenylalanyl-phenylalaninamide

Networked: 64 relevant articles (1 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - endomorphin 2: 64

Experts

1.	Zhang, Ting: 5 articles (01/2019 - 03/2015)
2.	Li, Yun-Qing: 4 articles (01/2016 - 09/2014)
3.	Kaczyńska, Katarzyna: 3 articles (10/2020 - 10/2016)
4.	Kleczkowska, Patrycja: 3 articles (10/2020 - 10/2016)
5.	Dai, Guang-Hai: 3 articles (09/2017 - 03/2015)
6.	Qian, Nian-Song: 3 articles (09/2017 - 03/2015)
7.	Wang, Ya-Yun: 3 articles (01/2016 - 09/2014)
8.	Moustafa, Shatha Rouf: 2 articles (06/2021 - 08/2020)
9.	Al-Dujaili, Arafat Hussein: 2 articles (01/2021 - 08/2020)
10.	Al-Hakeim, Hussein Kadhem: 2 articles (01/2021 - 08/2020)

Related Diseases

1.	Hypoxia (Hypoxemia) 03/26/2008 - "The present study attempts to evaluate the protective effects of endomorphin 1 (EM1), endomorphin 2 (EM2), and morphine (Mor) in an in vitro mouse brain mitochondria anoxia-reoxygenation model. "
2.	Pain (Aches) 10/01/2019 - "Therefore, endomorphin-2 plays an important role in the modulation of orthodontic pain both centrally and peripherally, probably through different pathways." 10/01/2019 - "Endomorphin-2 demonstrates potent antinociceptive effects in various pain models. " 09/01/2014 - "Endomorphin-2 (EM2) demonstrates a potent antinociceptive effect in pain modulation. " 04/01/2009 - "Effects of transgene-mediated endomorphin-2 in inflammatory pain." 10/01/2019 - "The results showed that following orthodontic tooth movement, endomorphin-2 expression levels in trigeminal ganglia were elevated on days 1, 3, 5, and 7. Orthodontic pain levels were increased on days 1, 3, and 5. The administration of endomorphin-2 into both trigeminal ganglia and periodontal tissues alleviated orthodontic pain. "
3.	Neuralgia (Stump Neuralgia) 09/01/2017 - "There is increasing evidence implicating the involvement of spinal endomorphin-2 (EM2) in neuropathic pain. " 01/01/2014 - "There is increasing evidence implicating the involvement of spinal endomorphin-2 (EM2) in neuropathic pain. " 01/01/2012 - "Effect of recombinant adenovirus coding for endomorphin-2 on neuropathic pain in rats." 12/15/2007 - "Engineering an endomorphin-2 gene for use in neuropathic pain therapy." 12/01/2017 - "Therefore, the present study was conducted to investigate the antinociceptive effects of endomorphin-1 (EM-1) and endomorphin-2 (EM-2) given centrally and peripherally in the SNI model of neuropathic pain in mice. "
4.	Inflammation (Inflammations) 01/01/2013 - "In addition, early in life inflammation combined with adult bladder inflammation decreased endomorphin-2 content in the thoracolumbar spinal cord. " 05/01/2002 - "While MOR was upregulated on peripheral and central nerve terminals, inflammation did not alter endomorphin-2 expression in nerve fibers either in the dorsal horn of the spinal cord or in subcutaneous tissue. " 05/01/2002 - "In the present study, we analyzed the expression of endomorphin-1, endomorphin-2 and MOR by immunohistochemistry in a model of Freund's complete adjuvant (FCA)-induced painful inflammation. " 11/07/2023 - "We tested whether: (1) MOR activation with an endogenous ligand, such as endomorphin-2, increases inspiratory burst amplitude, (2) disinhibition of GABAergic or glycinergic inhibitory synaptic transmission is involved, and (3) inflammation alters endomorphin-2 effects. " 04/01/2009 - "HSV-mediated endomorphin-2 expression reduced nocisponsive behaviors in response to mechanical and thermal stimuli after injection of complete Freund's adjuvant (CFA) into the paw, and reduced peripheral inflammation measured by paw swelling after injection of CFA. "
5.	Adenocarcinoma 04/01/2005 - "In the present study, [125I]endomorphin-2 has been used to characterize mu-opioid-binding sites on transplantable mouse mammary adenocarcinoma cells. " 04/01/2005 - "Binding of endomorphin-2 to mu-opioid receptors in experimental mouse mammary adenocarcinoma." 01/01/2005 - "The binding studies with membranes of mouse mammary adenocarcinoma cells have shown significantly higher Bmax values for endomorphin-1 and endomorphin- 2 (806 and 671, respectively) than for morphiceptin (131), a well-known specific micro-opioid receptor ligand. "

Related Drugs and Biologics

1.	endomorphin 1
2.	Morphine (MS Contin)
3.	Opioid Analgesics (Opioids)
4.	Peptides (Polypeptides)
5.	Opioid Peptides (Opioid Peptide)
6.	mu Opioid Receptors (mu Opioid Receptor)
7.	Opioid Receptors (Opioid Receptor)
8.	Ligands
9.	Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)
10.	Formaldehyde (Formol)

Related Therapies and Procedures

1.	Tooth Movement Techniques
2.	Spinal Injections
3.	Analgesia
4.	Therapeutics