|1.||Tuboly, Gabor: 4 articles (10/2011 - 06/2007)|
|2.||Przewlocka, Barbara: 3 articles (12/2013 - 04/2004)|
|3.||Benedek, Gyorgy: 3 articles (10/2011 - 06/2007)|
|4.||Horvath, Gyöngyi: 3 articles (05/2010 - 02/2004)|
|5.||Zagon, Ian S: 3 articles (12/2007 - 04/2003)|
|6.||McLaughlin, Patricia J: 3 articles (12/2007 - 04/2003)|
|7.||McDougall, Jason J: 3 articles (10/2005 - 01/2004)|
|8.||Mika, Joanna: 2 articles (12/2013 - 05/2004)|
|9.||Toth, Istvan: 2 articles (01/2013 - 06/2008)|
|10.||Blanchfield, Joanne T: 2 articles (01/2013 - 06/2008)|
11/01/2010 - "Peripheral antinociceptive effects of the cyclic endomorphin-1 analog c[YpwFG] in a mouse visceral pain model."
01/01/1999 - "These are the first data to demonstrate decreased responsivity in models of both acute and inflammatory pain after intrathecal administration of endomorphin-1 and -2 in awake rats."
11/01/2010 - "This study reports that c[YpwFG] is more lipophilic and resistant to enzymatic hydrolysis than endomorphin-1 and produces preemptive antinociception in a mouse visceral pain model when injected intraperitoneally (i.p.) or subcutaneously (s.c.) before 0.6% acetic acid, employed to evoke abdominal writhing (i.p. "
09/01/2000 - "These studies were done to determine whether the antinociception induced by endomorphin-1 and endomorphin-2 given supraspinally was mediated by the activation of different descending pain control pathways in the mouse. "
12/01/2013 - "The NOS inhibitors regardless of the type of pain enhanced morphine antinociception and, to a lesser extent, altered the effects of endomorphin-1, an opioid ligand with a peptidergic structure."
10/01/2011 - "The goal of this study was to characterize the antinociceptive potential of NADA on inflammatory thermal hyperalgesia in rats at spinal level, and to determine its interaction with endomorphin-1 (EM) at the spinal level. "
10/01/2001 - "The results demonstrate that continuous administration of endomorphin-1 is an effective method of inhibiting thermal hyperalgesia in rats. "
10/01/2001 - "On the inflamed side, endomorphin-1 dose-dependently decreased the thermal hyperalgesia during continuous administration. "
02/19/1999 - "Endomorphin-1 and -2 (2.5 and 5 microg i.t.) dose-dependently antagonized allodynia. "
07/24/1999 - "The results showed that OFQ at the supraspinal level produces hyperalgesia and is antagonistic to endomorphin-1, while at the spinal level it produces analgesia and is synergic with endomorphin-1. "
|4.||Neuralgia (Stump Neuralgia)
02/19/1999 - "In a neuropathic pain model (sciatic nerve crushing in rats), endomorphin-1 and -2 (5 microg i.t.) had a statistically significant effect on the tail-flick latency and on the cold-water tail flick latency. "
12/01/2013 - "For neuropathic pain, the ED50 value for morphine was much higher (43.2 μg) than that of endomorphin-1 (9.2 μg) in von Frey test. "
01/01/1999 - "Spinal analgesic effects of endomorphin-1 and endomorphin-2 were studied during acute, inflammatory, and neuropathic pain in rats chronically implanted with intrathecal cannulas. "
12/01/2013 - "Moreover, in neuropathic pain, the effects of morphine were more potentiated by L-NAME, TRIM, 7-NI and 1400W (12×, 8.6×, 4.1× and 5.3×, respectively) than were the effects of endomorphin-1 (2.7×, 4.3×, 3.4× and 2.1×, respectively) in the von Frey test. "
01/01/2013 - "Endomorphin-1 and -2, two endogenous opioid peptides, have been shown to produce potent antinociception in rodent models of acute and neuropathic pain with less undesirable side effects than opioid alkaloids. "
04/01/2004 - "These findings demonstrate that peripheral administration of endomorphin-1 reduces knee joint blood flow and this effect is not sustainable during advanced inflammation. "
01/01/2004 - "Attenuation of knee joint inflammation by peripherally administered endomorphin-1."
10/01/1999 - "Modulation of peripheral inflammation by locally administered endomorphin-1."
05/01/2002 - "In the present study, we analyzed the expression of endomorphin-1, endomorphin-2 and MOR by immunohistochemistry in a model of Freund's complete adjuvant (FCA)-induced painful inflammation. "
05/01/2010 - "Our goal was to determine the antinociceptive potency of the endogenous cannabinoid 2-arachidonoyl-glycerol (2-AG), and its interaction with endomorphin-1 (EM1) at joint level in the rat inflammation model. "
|2.||Morphine (MS Contin)
|3.||Opioid Receptors (Opioid Receptor)
|4.||Opioid Peptides (Opioid Peptide)
|6.||mu Opioid Receptors (mu Opioid Receptor)
|8.||Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)