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artemisitene

RN given for (3R-(3alpha,5abeta,6beta,8abeta,12beta,12aR*))-isomer; structure in first source

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Free Radicals: 15039
  - Reactive Oxygen Species: 39360
    - Artemisinins: 238
      - artemisitene: 7
Organic Chemicals: 133
- Free Radicals: 15039
  - Reactive Oxygen Species: 39360
    - Artemisinins: 238
      - artemisitene: 7
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - Artemisinins: 238
        artemisitene: 7

Experts

1.	Cui, Ke: 2 articles (01/2018 - 01/2016)
2.	Chen, Jian: 1 article (01/2018)
3.	Ji, Kaiyuan: 1 article (01/2018)
4.	Li, Wenjuan: 1 article (01/2018)
5.	Xu, Shuxiang: 1 article (01/2018)
6.	Xu, Yang: 1 article (01/2018)
7.	Chen, Weimin: 1 article (01/2016)
8.	Li, Jinwei: 1 article (01/2016)
9.	Li, Shanshan: 1 article (01/2016)
10.	Liu, Bo: 1 article (01/2016)

Related Diseases

1.	Sepsis (Septicemia) 01/01/2023 - "In the present study, we aimed to elucidate the pathways and explore the impact of artemisitene (ATT) on ferroptosis in sepsis-induced liver injury. "
2.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 06/06/2023 - "The present study investigated the therapeutic potential of 13 medicinal plants, such as Litsea cubeba, Artemisia anomala, Piper nigrum, Morus macroura, and Agrimonia pilosa, and 29 phytocompounds such as artemisitene, morroniside, protopine, ferulic acid, quercetin, picroside II, and hydroxytyrosol on in vitro and in vivo models of inflammatory bowel diseases (IBD), with a focus on their effects on the NLRP3 inflammasome. "
3.	Neoplasms (Cancer) 01/01/2018 - "Here we demonstrate that artemisitene (ATT), a natural derivative of the antimalarial drug artemisinin, selectively induces DNA double-stranded breaks (DSBs) and apoptosis in various human cancer cells by suppressing the expression of topoisomerases in human cancer cells. " 08/15/2011 - "Cancer and trypanosomal cells did not reveal cross-resistance among other compounds of Artemisia annua, namely the artemisinin-related artemisitene and arteanuine B as well as the unrelated compounds, scopoletin and 1,8-cineole. "
4.	Carcinogenesis 01/01/2018 - "Artemisitene suppresses tumorigenesis by inducing DNA damage through deregulating c-Myc-topoisomerase pathway."
5.	Lung Injury 01/01/2016 - "Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury." 01/01/2016 - "Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury."

Related Drugs and Biologics

1.	Inflammasomes
2.	Quercetin
3.	morroniside
4.	picroside II
5.	protopine
6.	3,4-dihydroxyphenylethanol (hydroxytyrosol)
7.	ferulic acid (sodium ferulate)
8.	artemisinin (artemisinine)
9.	NF-kappa B (NF-kB)
10.	Scopoletin