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tegaserod (Zelnorm)

a nonbenzamide 5-hydroxytryptamine(4) agonist; used in treatment of irritable bowel syndrome; marketing suspended 2007 in US due to higher incidence of MI, stroke, and unstable angina; structure given in first source
Also Known As:
Zelnorm; 5-methoxyindol-3-carboxaldehyde amino(pentylamino)methylenehydrazone hydrogen maleate; HTF 919; SDZ HTF 919; SDZ HTF-919; Zelmac; tegaserod maleate
Networked: 261 relevant articles (65 outcomes, 66 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Chey, William D: 10 articles (01/2022 - 01/2003)
2. Talley, Nicholas J: 7 articles (08/2008 - 05/2002)
3. Tack, Jan: 6 articles (10/2022 - 08/2002)
4. Prous, J R: 5 articles (09/2007 - 01/2003)
5. Rabasseda, X: 5 articles (09/2007 - 01/2003)
6. Lacy, Brian E: 4 articles (01/2022 - 01/2002)
7. Earnest, David L: 4 articles (06/2010 - 11/2006)
8. Pfannkuche, Hans-Juergen: 4 articles (10/2009 - 11/2004)
9. Shetzline, Michael A: 4 articles (05/2008 - 11/2005)
10. Tack, J: 3 articles (02/2011 - 12/2005)

Related Diseases

1. Constipation
2. Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
3. Abdominal Pain (Pain, Abdominal)
01/01/2004 - "Tegaserod did not significantly improve the patients' individual symptoms of abdominal pain and discomfort although bowel habit showed a statistically significant improvement with tegaserod 4 mg and there was a non-significant trend in favour of tegaserod 12 mg. When GI symptoms were assessed separately, those indicative of GI motility such as number of bowel movements and days without bowel movements were generally improved with tegaserod although the proportion of patients experiencing diarrhoea was significantly higher in the tegaserod 12 mg group compared with placebo (RR 2.75, 95% CI 1.90, 3.97), with a number needed to harm (NNH) of 20. "
11/01/2004 - "Patients who were treated with tegaserod had an overall improvement in IBS symptoms (Subject's Assessment of Global Relief) as well as in secondary end points, such as abdominal pain and discomfort, stool consistency, change in bowel movements and relief of bloating. "
01/01/2004 - "Tegaserod has been assessed in a number of international multicentre trials and its use leads to an improvement in abdominal pain and bowel dysfunction as well as global well-being, at the expense of remarkably few adverse effects. "
04/01/2003 - "In clinical trials with tegaserod, the Subject's Global Assessment (SGA) of Relief (a global measure that includes overall wellbeing, abdominal pain/discomfort, and bowel function) was used to identify responders. "
07/01/2006 - "Tegaserod, a 5-HT(4) agonist, demonstrates superiority over placebo in improving bowel frequency and stool consistency and alleviating abdominal pain and bloating in women with C-IBS. "
4. Pain (Aches)
5. Parkinson Disease (Parkinson's Disease)

Related Drugs and Biologics

1. Serotonin (5 Hydroxytryptamine)
2. 5-HT4 Serotonin Receptors
3. prucalopride
4. Lubiprostone
5. tegaserod (Zelnorm)
6. alosetron (Lotronex)
7. Laxatives
8. Serotonin 5-HT4 Receptor Agonists
9. Cisapride (Propulsid)
10. Glycopyrrolate (Glycopyrronium Bromide)

Related Therapies and Procedures

1. Therapeutics
2. Retreatment
3. Acupuncture Points (Acupuncture Point)
4. Chinese Traditional Medicine (Traditional Chinese Medicine)
5. Rectal Administration