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RS 79948-197
structure given in first source
Also Known As:
(8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(ethylsulfonyl)-6H-isoquino(2,1-g)(1,6)naphthyridine; RS 79948; RS-79948; RS-79948-197; RS79948
Networked:
5
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Isoquinolines: 34
RS 79948-197: 5
Naphthyridines: 2
RS 79948-197: 5
Experts
1.
Koss, Michael C
: 3 articles (01/2005 - 04/2004)
2.
Yu, Yongxin
: 3 articles (01/2005 - 04/2004)
3.
Ramage, Andrew G
: 1 article (04/2004)
4.
Koss, M C
: 1 article (02/2003)
Related Diseases
1.
Substance-Related Disorders (Drug Abuse)
10/01/2022 - "
Future studies should clarify if the dual α2-adrenoceptor- and D2-receptor antagonistic action might endow RS 79948 with potential therapeutic relevance in the treatment of schizophrenia, drug dependence, depression and Parkinson's disease.
"
2.
Schizophrenia (Dementia Praecox)
10/01/2022 - "
Future studies should clarify if the dual α2-adrenoceptor- and D2-receptor antagonistic action might endow RS 79948 with potential therapeutic relevance in the treatment of schizophrenia, drug dependence, depression and Parkinson's disease.
"
3.
Parkinson Disease (Parkinson's Disease)
10/01/2022 - "
Future studies should clarify if the dual α2-adrenoceptor- and D2-receptor antagonistic action might endow RS 79948 with potential therapeutic relevance in the treatment of schizophrenia, drug dependence, depression and Parkinson's disease.
"
4.
Mydriasis
12/01/2004 - "
The alpha2-adrenergic antagonist, RS 79948 (0.3 mg/kg, i.v.), potentiated mydriasis of the normal eye, but was without either a potentiating or inhibitory effect on the mydriasis of the sympathectomized eye.
"
04/12/2004 - "
WAY 100635 (1 mg/kg, i.v.) did not antagonize the evoked reflex mydriasis, which, however, was blocked by RS 79948 (0.3 mg/kg, i.v.).
"
02/01/2003 - "
3. The highly selective alpha2-adrenoceptor antagonist, RS-79948, administered either before or after rilmenidine, antagonized rilmenidine-induced mydriasis.
"
01/15/2005 - "
Two antagonists (RS 79948 for alpha(2)-adrenoceptors and efaroxan for imidazoline I(1) receptors) were used to antagonize the mydriasis elicited by those three agonists, with antagonistic potencies calculated.
"
5.
Catalepsy
10/01/2022 - "
RS 79948 antagonized, less effectively than atipamezole, raclopride-induced catalepsy.
"
Related Drugs and Biologics
1.
Imidazolines
2.
Raclopride
3.
Adrenergic Receptors (Adrenergic Receptor)
4.
Rilmenidine (Hyperium)
5.
N- (2- (4- (2- methoxyphenyl)- 1- piperazinyl)ethyl)- N- (2- pyridinyl)cyclohexanecarboxamide
6.
efaroxan
7.
atipamezole