|1.||Nykjaer, Anders: 9 articles (12/2014 - 11/2007)|
|2.||Willnow, Thomas E: 8 articles (12/2015 - 02/2007)|
|3.||Kjolby, Mads: 5 articles (08/2015 - 09/2010)|
|4.||Breiderhoff, Tilman: 4 articles (12/2015 - 11/2007)|
|5.||Carlo, Anne-Sophie: 4 articles (09/2014 - 05/2008)|
|6.||Lee, Joseph H: 4 articles (01/2011 - 02/2007)|
|7.||Rabbani, Hodjattallah: 3 articles (12/2015 - 07/2009)|
|8.||Jeddi-Tehrani, Mahmood: 3 articles (12/2015 - 07/2009)|
|9.||Bentzon, Jacob F: 3 articles (08/2015 - 02/2014)|
|10.||Jauberteau, Marie-Odile: 3 articles (09/2014 - 01/2011)|
02/04/2014 - "We here identify sortilin, encoded by the hypercholesterolemia-risk gene SORT1, as a high-affinity sorting receptor for PCSK9. "
09/08/2010 - "Absence of sortilin in gene-targeted mice reduces secretion of lipoproteins from the liver and ameliorates hypercholesterolemia and atherosclerotic lesion formation in LDL receptor-deficient animals. "
09/01/2014 - "The activity of sortilin is essential for proper function of not only neurons but also non-neuronal cell types, and receptor (dys)function emerges as a major cause of malignancies, including hypercholesterolemia, retinal degeneration, neuronal cell loss in stroke and spinal cord injury, or Alzheimer's disease and other neurodegenerative disorders. "
|2.||Alzheimer Disease (Alzheimer's Disease)
01/01/2015 - "Several studies have established the sortilin-related receptor gene (SORL1) as a susceptibility locus for Alzheimer's disease (AD). "
01/01/2015 - "In previous studies, we reported that the sortilin-related receptor, L (DLR class) A repeats containing (SORL1) gene single nucleotide polymorphisms (SNPs) are associated with the risk of sporadic Alzheimer's disease (SAD) in the Han Chinese population. "
04/01/2014 - "The neuronal sortilin-related receptor (SORL1) has been reported to modulate the risk of Alzheimer's disease (AD) in a variety of populations, but replication studies have been inconsistent. "
10/01/2013 - "In conclusion, this study shows that sortilin expression is increased in the AD brain in human and mice and that Aβ₄₂ oligomer increases sortilin gene and protein expression through p75(NTR) and RhoA signaling pathways, suggesting a potential physiological interaction of Aβ₄₂ and sortilin in Alzheimer's disease."
10/01/2013 - "The aim of this study was to investigate the expression and regulation of sortilin in Alzheimer's disease (AD). "
12/01/2015 - "The aim of this study was to produce a monoclonal antibody against a synthetic peptide derived from extracellular N-terminal region of sortilin to be used as a tool for investigating sortilin characteristics in ovarian carcinoma. "
07/01/2014 - "The aim of this study was, therefore, to investigate the functional role of sortilin in survival of ovarian carcinoma cell line. "
12/01/2015 - "Sortilin, as a member of Vps10p-domain sorting receptor family, is overexpressed in a number of malignancies, including ovarian carcinoma. "
07/01/2014 - "Expression of sortilin was knocked down using RNAi technology in the ovarian carcinoma cell line, Caov-4. "
07/01/2014 - "Our preliminary data on the protein expression of SORT1 in ovarian carcinoma tissues showed that sortilin was overexpressed in ovarian carcinoma patients and cell lines, while non-malignant ovaries expressed comparably lower amount of this protein. "
04/30/2015 - "In this study, sortilin was analyzed by immunohistochemistry in a series of 318 clinically annotated breast cancers and 53 normal breast tissues. "
04/30/2015 - "Sortilin was detected in epithelial cells, with increased levels in cancers, as compared to normal tissues (p = 0.0088). "
09/15/2014 - "Sortilin is already known to be important for cancer cell function. "
07/01/2014 - "As it was suspected from overexpression of sortilin in ovarian tumor cells, a cell survival role for sortilin can be deduced from these results. "
08/01/2013 - "We also observed that tumors expressed proBDNF, p75NTR, and sortilin in the same cells with different subcellular distributions, suggesting an autocrine or paracrine loop. "
12/15/2015 - "The aim of our study was to elucidate the distribution of sortilin in different immune cell types in mice and humans and to analyze its function in autoimmune CNS inflammation. "
12/01/2014 - "Together, these data demonstrate that sortilin influences cytokine secretion and that targeting sortilin in immune cells attenuates inflammation and reduces atherosclerosis. "
12/01/2014 - "Transfer of sortilin-deficient BM into irradiated atherosclerotic mice reduced atherosclerosis and systemic markers of inflammation. "
|2.||LDL Receptors (LDL Receptor)
|4.||Amyloid (Amyloid Fibrils)
|5.||Oxidopamine (6 Hydroxydopamine)
|8.||Nerve Growth Factor (NGF)
|10.||Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)
|1.||Enzyme Replacement Therapy