|1.||Imagawa , J I: 1 article (04/2001)|
|2.||Fukazawa, M: 1 article (04/2001)|
|3.||Suzuki, Y: 1 article (04/2001)|
|4.||Adachi, Y: 1 article (04/2001)|
|5.||Kuromaru, O: 1 article (04/2001)|
|6.||Tamura, K: 1 article (04/2001)|
|7.||Akima, M: 1 article (04/2001)|
|1.||Cardiac Arrhythmias (Arrythmia)
04/01/1998 - "In this study, therefore, the protective effect of CP-060S against ischaemia- and reperfusion-induced arrhythmia was evaluated in anesthetized rats. "
04/01/1998 - "6. These results suggest that CP-060S inhibits both ischaemia- and reperfusion-induced arrhythmia. "
04/01/1998 - "5. In the ischaemia-induced arrhythmia model, CP-060S (300 microg kg(-1)) significantly decreased the incidence of VF from 75% to 29%, whereas diltiazem (1 mg kg(-1)) was ineffective. "
|2.||Myocardial Ischemia (Ischemic Heart Diseases)
01/01/1999 - "Thus the inhibition of the noninactivating sodium current may be the primary reason for the antiischemic effect of CP-060S and could become a new cytoprotective principle in the treatment of patients with ischemic heart disease."
04/01/2001 - "In conclusion, CP-060S exerted a more potent and sustained protection against myocardial ischemia evoked by methacholine than diltiazem. "
09/26/1996 - "Pretreatment of cardiomyocytes with more than 300 nM of CP-060S or CP-060R for 30 min provided almost complete protection against the veratridine-induced cell contracture; in CP-060S(1 microM)-treated myocytes, [Ca2+]i were minimal and partially elevated from 42 +/- 5 nM to 72 +/- 14 nM after 5 min of veratridine superfusion. "
03/01/1998 - "CP-060S, a novel cardioprotective drug, limits myocardial infarct size in anesthetized dogs."
03/01/1998 - "The myocardial infarct size (IS)-limiting effect of CP-060S, a novel cardioprotective drug that prevents Na+-, Ca2+-overload and has Ca2+ channel-blocking activity, was compared with that of diltiazem, a pure Ca2+ antagonist, to determine whether the prevention of Na+-, Ca2+-overload contributes to this IS-limiting effect. "
02/19/1999 - "The anti-ischemic effects of CP-060S during pacing-induced ischemia in anesthetized dogs."
02/19/1999 - "We compared the anti-ischemic effects of CP-060S with those of diltiazem, a Ca2+ channel blocker, and R56865, N-[1-[4-(4-fluorophenoxy)butyl]-4-piperidinyl]-N-methyl-2-benzothiazo lamine, a Na+-, Ca2+-overload inhibitor, in a canine pacing-induced ischemia model. "
|2.||Methacholine Chloride (Methacholine)
|4.||Sodium Channels (Sodium Channel)