splase

constructed by genetically fusing the DNA-cleavage domain of FokI restriction endonuclease with the zinc-finger DNA-binding domain of transcription factor Sp1; recognizes a 10-bp sequence of the long terminal repeat of HIV-1 DNA at Sp1 sites and cleaves phosphodiester bonds upstream of thebinding sequence

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Deoxyribonucleases: 1259
        Endodeoxyribonucleases
        DNA Restriction Enzymes: 848
        Type II Site-Specific Deoxyribonucleases
        splase
      - Endonucleases: 1227
        Endodeoxyribonucleases
        DNA Restriction Enzymes: 848
        Type II Site-Specific Deoxyribonucleases
        splase
  - DNA Restriction-Modification Enzymes: 41
    - DNA Restriction Enzymes: 848
      - Type II Site-Specific Deoxyribonucleases
        splase
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Kruppel-Like Transcription Factors: 252
      - Sp Transcription Factors: 65
        Sp1 Transcription Factor: 260
        splase
  - DNA-Binding Proteins: 2009
    - Kruppel-Like Transcription Factors: 252
      - Sp Transcription Factors: 65
        Sp1 Transcription Factor: 260
        splase

splase

Bio-Agent Context: Research Results