xanthohumol

from hop plant, Humulus lupulus

Also Known As:

(2E)-1-(2,4-dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl)-3-(4-hydroxyphenyl)-2-propen-1-one; (2E)-3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxy-3-(3-methyl-2-buten-1-yl)phenyl)-2-propen-1-one; 1-(2,4-dihydroxy-6-methoxy-3-(3-methyl-2-butenyl)phenyl)-3-(4-hydroxyphenyl)-2-propen-1-one; 2,4,4',6-tetrahydroxy-3-(3,3-dimethylallyl)chalcone; Xantho-Flav; XanthoFlav; desmethylxanthohumol

Networked: 255 relevant articles (22 outcomes, 48 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Stevens, Jan F: 14 articles (12/2021 - 05/2004)
2.	Miranda, Cristobal L: 11 articles (12/2021 - 02/2007)
3.	Maier, Claudia S: 9 articles (12/2021 - 12/2016)
4.	Hellerbrand, Claus: 9 articles (01/2021 - 02/2010)
5.	Bobe, Gerd: 7 articles (11/2021 - 07/2013)
6.	Gombart, Adrian F: 7 articles (11/2021 - 12/2016)
7.	Soares, Raquel: 7 articles (10/2021 - 02/2007)
8.	Heilmann, Jörg: 6 articles (02/2013 - 10/2009)
9.	Gerhäuser, Clarissa: 6 articles (08/2010 - 03/2004)
10.	Krajka-Kuźniak, Violetta: 5 articles (12/2021 - 02/2013)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2012 - "These results suggest that the protective effects of xanthohumol in this toxic liver injury model involves direct mechanisms related to its ability to block both hepatic inflammation and the activation of hepatic stellate cells, presumable at least in part via decreasing NFκB activity. " 01/01/2023 - "Xanthohumol (Xn) displays various medicinal properties, including anti-inflammation, antioxidative, and enhancing autophagic flux. " 05/01/2021 - "In various maladies, an anti-inflammatory effect has been demonstrated for Xanthohumol (XN); while OA is an inflammation related disease. " 11/01/2017 - "In conclusion, xanthohumol treatment modulated the inflammation and apoptosis of aged brains, exerting a protective effect on damage induced by aging." 08/30/2017 - "Diabetes exhibits increased inflammation, angiogenesis, and apoptosis, three processes attenuated by xanthohumol (XN). "
2.	Neoplasms (Cancer) 07/01/2023 - "Previous studies have shown that xanthohumol was effective against various types of cancer, but the mechanisms, especially the direct targets for xanthohumol to exert an anticancer effect, remain elusive. " 06/15/2012 - "The prenylflavonoid xanthohumol (XN) has shown in vitro and in vivo therapeutic potential against a range of tumors. " 01/01/2022 - "Briefly, our studies revealed a novel mechanism by which Xanthohumol exerted its anti-tumor activity in a PUMA-dependent manner in NSCLC cells." 01/01/2022 - "Recently studies have shown the profound anti-tumor activities of Xanthohumol in multiple cancer models. " 01/01/2022 - "Xanthohumol is one of the prenylated phytoflavonoid that has demonstrated key anti-cancer activities in in vitro (anti proliferation of cancer cell lines) and in vivo (animal models of xenograft tumours) studies, and has been explored from different dimensions for targeting cancer subtypes. "
3.	Hepatocellular Carcinoma (Hepatoma) 02/01/2013 - "The aim of this study was to investigate whether xanthohumol may exert chemoprotective activity through the modulation of the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway in immortalized normal THLE-2 hepatocytes and a hepatocellular carcinoma HepG2 cell line. " 11/01/2008 - "In this study, the inhibitory effects of xanthohumol on human hepatocellular carcinoma cell lines were investigated. " 08/15/2007 - "The aim of this study was to reveal the possible anti-genotoxic activity of xanthohumol in metabolically competent human hepatoma HepG2 cells, by use of the comet assay. " 03/09/2019 - "Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines." 01/01/2015 - "Xanthohumol inhibits Notch signaling and induces apoptosis in hepatocellular carcinoma."
4.	Breast Neoplasms (Breast Cancer) 10/01/2014 - "The purpose of this study was to investigate the effects of xanthohumol on breast cancer cell proliferation. " 04/15/2020 - "Prostate and breast cancer cells death induced by xanthohumol investigated with Fourier transform infrared spectroscopy." 12/10/2019 - "Both biotinylated derivatives showed slightly higher anticancer activity than xanthohumol (1) towards all types of tested breast cancer cells. " 01/01/2018 - "Inhibition of breast cancer cell survival by Xanthohumol via modulation of the Notch signaling pathway in vivo and in vitro." 01/01/2018 - "Effect of xanthohumol on Th1/Th2 balance in a breast cancer mouse model."
5.	Prostatic Neoplasms (Prostate Cancer) 09/01/2010 - "Growth inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalone present in hops, in human prostate cancer cells." 02/08/2007 - "The purpose of this study was to investigate the anti-tumorigenic effects of xanthohumol (XN), the major prenylflavonoid in hops, on prostate cancer and benign prostate hyperplasia. " 12/06/2012 - "Xanthohumol impairs human prostate cancer cell growth and invasion and diminishes the incidence and progression of advanced tumors in TRAMP mice." 12/06/2012 - "In this study, we have used human hormone-resistant prostate cancer cells, DU145 and PC3, as an in vitro model to assess the efficacy of xanthohumol (XN) against cell growth, motility and invasion. " 06/22/2016 - "The findings suggest that xanthohumol is a compound of potential use in chemoprevention of prostate cancer due to its sensitization of cancer cells to TRAIL-mediated apoptosis. "

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4.	human ERBB2 protein
5.	Apolipoproteins E (ApoE)
6.	Amines
7.	Toll-Like Receptor 4
8.	tert-Butylhydroperoxide
9.	Lipopolysaccharides
10.	Benzo(a)pyrene

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention
3.	Aftercare (After-Treatment)
4.	Ovariectomy (Oophorectomy)
5.	Chinese Traditional Medicine (Traditional Chinese Medicine)