|1.||Hedlund, Peter B: 5 articles (01/2014 - 11/2005)|
|2.||Leopoldo, Marcello: 3 articles (01/2015 - 02/2011)|
|3.||Lacivita, Enza: 3 articles (01/2015 - 02/2011)|
|4.||Hamon, Michel: 3 articles (11/2012 - 05/2008)|
|5.||Cho, Soo Young: 2 articles (06/2015 - 04/2015)|
|6.||Oh, Jin Myung: 2 articles (06/2015 - 04/2015)|
|7.||Lee, Hyung Gon: 2 articles (06/2015 - 04/2015)|
|8.||Choi, Jeong Il: 2 articles (06/2015 - 04/2015)|
|9.||Yoon, Myung Ha: 2 articles (06/2015 - 04/2015)|
|10.||Ki, Hyoung Gon: 2 articles (06/2015 - 04/2015)|
05/01/2013 - "In this study, we investigated the effect of blocking 5-HT7 receptor signaling in experimental colitis with a view to develop an improved therapeutic strategy in intestinal inflammatory disorders. "
01/01/2014 - "5-HT7 receptors are expressed in the gut and very recently, we have shown evidence of 5-HT7 receptor expression on intestinal immune cells and demonstrated a key role for 5-HT7 receptors in generation of experimental colitis. "
05/01/2013 - "Inhibition of 5-HT7 receptor signaling with SB-269970 ameliorated both acute and chronic colitis induced by DSS. "
09/01/2014 - "In this study, we investigated the role of 5-HT7 receptor (5-HT7R) in the induction and development of intestinal inflammation using a mouse model of acute and chronic colitis and human patients with Crohn's disease (CD). "
05/01/2013 - "Colitis was induced with dextran sulfate sodium (DSS) or dinitrobenzene sulfonic acid (DNBS) in mice treated with selective 5-HT7 receptor antagonist SB-269970, as well as in mice lacking 5-HT7 receptor (5-HT7(-/-)) and irradiated wild-type mice reconstituted with bone marrow cells harvested from 5-HT7(-/-) mice. "
12/01/1997 - "Correlation between 5-HT7 receptor affinity and protection against sound-induced seizures in DBA/2J mice."
12/01/1997 - "The present study was undertaken to determine whether antagonism of the newly identified 5-HT7 receptor may protect DBA/2J mice from audiogenic seizures by attempting to correlate in vivo potency of compounds with their affinity at the 5-HT7 receptor. "
12/01/1997 - "All compounds used in the correlation were shown to be antagonists at the 5-HT7 receptor and a statistically significant correlation was observed between 5-HT7 affinity and doses for half-maximal response (ED50) for protection of DBA/2J mice from sound-induced seizures (r = 0.80; P < 0.05). "
05/01/2008 - "In particular, 5-HT7 receptor agonists were particularly effective at reducing allodynia in sciatic nerve-ligated rats, but were completely ineffective in infraorbital nerve-ligated rats. "
08/01/2012 - "5-HT7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice."
01/01/2014 - "The data indicate that 5-HT7 receptor agonists can have neuroprotective effects against N-methyl-d-aspartate-induced toxicity, modulate neuronal plasticity in rats, enhance morphine-induced antinociception and alleviate hyperalgesia consecutive to nerve lesion in neuropathic animals."
05/15/2013 - "Microinjection of selective 5-HT1A, 5-HT2, 5-HT3, 5-HT4, 5-HT5A, 5-HT6 and 5-HT7 receptor antagonists, 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine hydrobromide (NAN-190) (10μg), cyproheptadine (50ng), granisetron hydrochloride (granisetron) (10μg), 1-[2-[(methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl1-methyl-1H-indole-3-carboxylate (GR113808) (5μg), SB699551 dihydrochloride (SB699551) (10μg), SB258585 dihydrochloride (SB258585) (2μg) or SB269970 hydrochloride (SB269970) (10μg) into the VLO 5-min prior to 5-HT (10μg) injection, all antagonized the 5-HT-induced inhibition of allodynia. "
|4.||Memory Disorders (Memory Loss)
05/01/2013 - "The role of 5-HT7 receptor antagonism in the amelioration of MK-801-induced learning and memory deficits by the novel atypical antipsychotic drug lurasidone."
05/01/2013 - "We previously reported that lurasidone and the selective 5-HT7 receptor antagonist, SB-656104-A improved learning and memory deficits induced by MK-801, an N-methyl-d-aspartate (NMDA) receptor antagonist, in the rat passive avoidance test. "
|5.||Alzheimer Disease (Alzheimer's Disease)
|2.||N- (2- (4- (1,2- benzisothiazol- 3- yl)- 1- piperazinylmethyl)- 1- cyclohexylmethyl)- 2,3- bicyclo(2.2.1)heptanedicarboximide
|3.||Dizocilpine Maleate (Dizocilpine)
|5.||Serotonin (5 Hydroxytryptamine)
|8.||Antidepressive Agents (Antidepressants)