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non-ribosomal peptide synthase

nrp - Non-Ribosomal Peptide/Polyketide; locus nrp is mutated in a swarming-defective Proteus mirabilis strain; 249 amino acid residues, MW 29.7 kDa; amino acid sequence in first source
Also Known As:
NRPS enzyme; NrpG synthase; bacillamide synthetase; non-ribosomal peptide synthetase; nonribosomal peptide synthase; nonribosomal peptide synthetase
Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Motoyama, Takayuki: 1 article (12/2021)
2. Osada, Hiroyuki: 1 article (12/2021)
3. Yun, Choong-Soo: 1 article (12/2021)
4. Chakraborty, Kajal: 1 article (05/2020)
5. Kizhakkekalam, Vinaya Kizhakkepatt: 1 article (05/2020)
6. Chooi, Yit-Heng: 1 article (01/2020)
7. Hu, Jinyu: 1 article (01/2020)
8. Lacey, Ernest: 1 article (01/2020)
9. Li, Hang: 1 article (01/2020)
10. Sobolev, Alexandre N: 1 article (01/2020)

Related Diseases

1. Bacterial Infections (Bacterial Infection)
2. Infections
01/01/2020 - "Here, we identified a putative polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) gene cluster (phm) that was upregulated in the pathogen Parastagonospora nodorum during its infection on wheat. "
10/01/2005 - "Genes coding for a non-ribosomal peptide synthetase and the beta chain of a propionyl CoA carboxylase were identified as possessing promoters that demonstrated enhanced activity following macrophage infection by C. "
08/15/2015 - "The compound enables iron scavenging capabilities upon host infection and is biosynthesized by a nonribosomal peptide synthetase featuring a polyketide synthase module. "
12/23/2021 - "These secondary metabolites include melanin, a polyketide compound required for rice infection; tenuazonic acid, a well-known mycotoxin produced by various plant pathogenic fungi and biosynthesized by a unique nonribosomal peptide synthetase-polyketide synthase hybrid enzyme; nectriapyrones, antibacterial polyketide compounds produced mainly by symbiotic fungi, including plant pathogens and endophytes, and pyriculols, phytotoxic polyketide compounds. "
05/01/2017 - "Inosine-5'-monophosphate dehydrogenase, serine hydroxy methyltransferase and alanyl-tRNA synthethase, involved in aminoacid and nucleotide metabolism, the protein with antioxidant activity alkyl hydroperoxide reductase and a non-ribosomal peptide synthetase responsible for the synthesis of the siderophore piscibactin have been identified as antigens induced in Phdp during S. senegalensis infection. "
3. Neoplasms (Cancer)
4. Tuberculosis (Tuberculoses)
5. Polyps

Related Drugs and Biologics

1. Polyketide Synthases
2. Anti-Bacterial Agents (Antibiotics)
3. Polyketides
4. Siderophores
5. Peroxiredoxins
6. Zinc
7. Thiazoles
8. Terpenes (Terpenoids)
9. Tenuazonic Acid
10. Serine (L-Serine)