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4'-thio-2'-deoxy-2'-methylidenecytidine
structure in first source
Also Known As:
4'-thio-DMDC
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrimidines: 510
Pyrimidine Nucleosides: 50
Cytidine: 535
Deoxycytidine: 307
4'-thio-2'-deoxy-2'-methylidenecytidine: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Pyrimidine Nucleosides: 50
Cytidine: 535
Deoxycytidine: 307
4'-thio-2'-deoxy-2'-methylidenecytidine: 1
Deoxyribonucleosides: 34
Deoxycytidine: 307
4'-thio-2'-deoxy-2'-methylidenecytidine: 1
Thionucleosides: 2
4'-thio-2'-deoxy-2'-methylidenecytidine: 1
Organic Chemicals: 133
Sulfur Compounds: 278
Thionucleosides: 2
4'-thio-2'-deoxy-2'-methylidenecytidine: 1
Related Diseases
1.
Sarcoma (Soft Tissue Sarcoma)
10/01/1996 - "
4'-Thio-DMDC exhibited potent antitumor activity against subcutaneously implanted murine sarcoma S-180 and human fibrosarcoma HT-1080 xenografts.
"
2.
Neoplasms (Cancer)
10/01/1996 - "
4'-Thio-DMDC inhibited the growth of various cell lines established from human solid cancers, particularly the growth of lung and bladder carcinomas and melanomas.
"
10/01/1996 - "
4'-Thio-DMDC is a poor substrate for cytidine deaminase, thus it is a promising agent for the treatment of malignant solid tumors because it will not be converted into its inactive uridine form.
"
3.
Melanoma (Melanoma, Malignant)
10/01/1996 - "
4'-Thio-DMDC inhibited the growth of various cell lines established from human solid cancers, particularly the growth of lung and bladder carcinomas and melanomas.
"
4.
Fibrosarcoma
10/01/1996 - "
4'-Thio-DMDC exhibited potent antitumor activity against subcutaneously implanted murine sarcoma S-180 and human fibrosarcoma HT-1080 xenografts.
"
5.
Carcinoma (Carcinomatosis)
10/01/1996 - "
4'-Thio-DMDC inhibited the growth of various cell lines established from human solid cancers, particularly the growth of lung and bladder carcinomas and melanomas.
"
Related Drugs and Biologics
1.
Uridine
2.
Cytidine Deaminase