HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

N- (1- ((2,4- diamino- 6- pteridinyl)methyl)- 3,4- dihydro - 2H- 1,4- benzothiazine- 7- carbonyl)- L- 2- aminoadipic acid

structure given in first source

Also Known As:

MX 68; MX-68

Networked: 9 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Asakura, Masanori: 1 article (04/2004)
2.	Asanuma, Hiroshi: 1 article (04/2004)
3.	Hori, Masatsugu: 1 article (04/2004)
4.	Kitakaze, Masafumi: 1 article (04/2004)
5.	Minamino, Tetsuo: 1 article (04/2004)
6.	Mori, Hidezo: 1 article (04/2004)
7.	Node, Koichi: 1 article (04/2004)
8.	Ogai, Akiko: 1 article (04/2004)
9.	Ogita, Hisakazu: 1 article (04/2004)
10.	Sanada, Shoji: 1 article (04/2004)

Related Diseases

1.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 08/01/1997 - "We conclude that MX-68 is beneficial for the treatment of autoimmune kidney disease in mice and may be useful for other related diseases such as systemic lupus erythematosus." 02/01/1997 - "Preventive effect of a novel antifolate, MX-68, in murine systemic lupus erythematosus (SLE)." 02/01/1997 - "We evaluated the preventive effects of a novel nonpolyglutamatable antifolate, MX-68, on two experimental murine models of systemic lupus erythematosus (SLE); NZBxNZW F1 (BWF1) mice and chronic graft-versus-host disease (GVHD) mice, in comparison with classical antifolate methotrexate (MTX). "
2.	Autoimmune Diseases (Autoimmune Disease) 07/01/1998 - "These data suggest that MX-68 may be useful for the treatment of autoimmune diseases including EAU and that the pathophysiology of EAU could be different from that of CIA." 08/01/1997 - "A novel antifolate, MX-68, inhibits the development of autoimmune disease in MRL/lpr mice."
3.	Kidney Diseases (Kidney Disease) 08/01/1997 - "We conclude that MX-68 is beneficial for the treatment of autoimmune kidney disease in mice and may be useful for other related diseases such as systemic lupus erythematosus." 08/01/1997 - "We compared a novel unpolyglutamable antifolate, MX-68, with polyglutamable antifolate, methotrexate (MTX), for treatment of an autoimmune kidney disease which develops spontaneously in MRL/Mp-lpr/lpr (MRL/lpr) mice. "
4.	Experimental Arthritis 10/01/1996 - "MX-68 dramatically suppressed the onset of collagen-induced arthritis (CIA) in mice when the drug was orally administered three times a week. " 07/01/1998 - "The present study was carried out to examine both the in vitro and in vivo effects of MX-68 on experimental autoimmune uveitis (EAU) and to compare its effect on collagen-induced arthritis (CIA) in rats. " 01/25/2002 - "(2) In vivo: Oral administration of MX-68 suppressed the development of collagen-induced arthritis in mice and adjuvant-induced arthritis in rats, in a similar fashion to that of methotrexate. "
5.	Uveitis 07/01/1998 - "The present study was carried out to examine both the in vitro and in vivo effects of MX-68 on experimental autoimmune uveitis (EAU) and to compare its effect on collagen-induced arthritis (CIA) in rats. " 07/01/1998 - "A novel non-polyglutamable anti-folate, MX-68, inhibits the induction of experimental autoimmune uveitis in rats."

Related Drugs and Biologics

1.	Methotrexate (Mexate)
2.	Folic Acid Antagonists
3.	Adenosine (Adenocard)
4.	Interleukin-1beta (Interleukin 1 beta)
5.	Ionomycin
6.	5'-Nucleotidase (5' Nucleotidase)
7.	2-Aminoadipic Acid (2 Aminoadipic Acid)
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Prednisolone (Predate)
10.	Folic Acid (Vitamin M)

Related Therapies and Procedures

1.	Oral Administration