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LE 540
structure given in first source
Also Known As:
LE-540; LE540
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
3-Ring Heterocyclic Compounds
Dibenzazepines: 4
LE 540: 2
Experts
1.
Alique, Matilde
: 1 article (01/2007)
2.
Herrero, Juan F
: 1 article (01/2007)
3.
Lucio-Cazana, Francisco Javier
: 1 article (01/2007)
Related Diseases
1.
Neuroblastoma
01/04/2007 - "
Pre-incubation of SH-SY5Y human neuroblastoma cells with either RAR-pan-antagonist LE540 or MAP kinase kinase 1 (MEK-1) inhibitor PD98059 resulted in the abolition of ATRA-induced COX-2 promoter activity, COX-2 protein expression and PGE2 production whereas the retinoid X receptor pan-antagonist HX531, the p38 MAPK inhibitor SB203580 or the c-Jun kinase inhibitor SP600125 did not have any effect.
"
2.
Breast Neoplasms (Breast Cancer)
05/28/1999 - "
In ZR-75-1 human breast cancer cells, cotreatment of LE135 and LE540 with all-trans-RA inhibited all-trans-RA-induced apoptosis of the cells, further demonstrating that RARbeta plays a role in RA-induced apoptosis of breast cancer cells.
"
Related Drugs and Biologics
1.
MAP Kinase Kinase 1
2.
p38 Mitogen-Activated Protein Kinases
3.
Retinoid X Receptors (Retinoid X Receptor)
4.
Dinoprostone (PGE2)
5.
Proteins (Proteins, Gene)
6.
Phosphotransferases (Kinase)
7.
diazepinylbenzoic acid
8.
pyrazolanthrone
9.
LE 135
10.
2- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- one