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LE 135

structure given in first source

Also Known As:

4-(5H-7,8,9,10-tetrahydro-5,7,7,10,10-pentamethylbenzo(e)naphtho(2,3-b)(1,4)diazepin-13-yl)benzoic acid; LE-135; LE135

Networked: 11 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Dibenzazepines: 4
      - LE 135: 11

Experts

1.	Bai, Aiping: 3 articles (11/2014 - 10/2009)
2.	Guo, Yuan: 3 articles (11/2014 - 10/2009)
3.	Lu, Nonghua: 3 articles (11/2014 - 10/2009)
4.	Fernández-Martínez, Ana B: 2 articles (01/2020 - 12/2012)
5.	Lucio-Cazaña, Francisco J: 2 articles (01/2020 - 12/2012)
6.	Chen, Jiang: 2 articles (06/2010 - 10/2009)
7.	Peng, Zhikang: 2 articles (06/2010 - 10/2009)
8.	García-Pastor, Coral: 1 article (01/2020)
9.	Yago-Ibáñez, Julia: 1 article (01/2020)
10.	Hasegawa, Takashi: 1 article (01/2015)

Related Diseases

1.	Colitis 11/01/2014 - "ATRA administration ameliorates DSS-induced colitis evidenced with decreased TNF level and CD68 expression, while LE135 leads to exacerbation of colitis. " 11/01/2014 - "The mice with DSS colitis were administered with vehicle, ATRA, or LE135. " 10/01/2009 - "Murine colitis was induced by intrarectal administration with TNBS at Day 1. Mice were then i.p.-treated with RA or LE135 daily for 7 days. "
2.	Anorectal Malformations 07/01/2011 - "In the present study, we investigated whether the retinoid antagonist, LE135, could prevent the induction of anorectal malformations (ARMs) in mice. "
3.	Inflammation (Inflammations) 01/01/2015 - "LE135 completely reversed the effects of ATRA on AHR, airway allergic inflammation and the number of Treg cells in the lungs. " 06/01/2010 - "On the contrary, LE135 showed the reverse effects in colon inflammation and cytokine profile. "
4.	Osteosarcoma (Osteogenic Sarcoma) 01/01/2023 - "The retinoic acid receptor beta (RARb) antagonist LE135, peroxisome proliferator activated receptor gamma (PPARg) antagonist T0070907, liver X receptor (LXR) agonist T0901317 and Rev-Erba agonist SR9011 significantly inhibited the proliferation of malignant osteosarcoma cells (U2OS, HOS-MNNG and Saos-2 cells) but did not inhibit the growth of normal osteoblasts. "
5.	Pain (Aches) 03/01/2014 - "Intraplantar injection of LE135 evoked pain-related behaviours. " 03/01/2014 - "LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels." 03/01/2014 - "Here, we demonstrate that LE135 [4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid], a selective antagonist of RARβ , is a potent activator of the capsaicin (TRPV1) and wasabi (TRPA1) receptors, two critical pain-initiating cation channels. "

Related Drugs and Biologics

1.	Retinoids
2.	PPAR gamma
3.	Small Interfering RNA (siRNA)
4.	Collagen Type II (Type II Collagen)
5.	Matrix Metalloproteinases (MMPs)
6.	Benzoic Acid (Potassium Benzoate)
7.	Retinoic Acid Receptors (Retinoic Acid Receptor)
8.	4,4'- Diisothiocyanostilbene- 2,2'- Disulfonic Acid (DIDS)
9.	Cytokines
10.	Tretinoin (Retinoic Acid)