17- (2- iodovinyl)- 11- chloromethylestradiol

high affinity ligand for estrogen receptors; may prove useful in imaging estrogen receptor-positive tumors; structure in first source

Also Known As:

17-(2-iodovinyl)-11-chloromethyl estradiol-17beta; CMIV-Z; Z-CMIV

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Neoplasms (Cancer) 09/01/1996 - "[125I]-Z-CMIV could open the way to new applications in the diagnosis and therapy of ER-positive breast cancers, especially those containing altered (variant) ERs." 01/01/1996 - "Biodistribution studies and quantitative scintigraphic imaging of human breast carcinoma xenografts in mice demonstrated continuous and selective accumulation of the [123I]Z-CMIV, in estrogen receptor (ER)-positive target tumors, with significantly high target/nontarget ratio up to 48 h post-injection. " 09/01/1996 - "Synthesis, structure and biological properties of Z-17alpha-(2-iodovinyl)-11beta-chloromethyl estradiol-17beta (Z-CMIV), a high affinity ligand for the characterization of estrogen receptor-positive tumors."
2.	Breast Neoplasms (Breast Cancer) 01/01/1996 - "Biodistribution studies and quantitative scintigraphic imaging of human breast carcinoma xenografts in mice demonstrated continuous and selective accumulation of the [123I]Z-CMIV, in estrogen receptor (ER)-positive target tumors, with significantly high target/nontarget ratio up to 48 h post-injection. "

1.	Therapeutics