|1.||Locatelli, Francesco: 8 articles (01/2011 - 07/2002)|
|2.||Scherhag, Armin: 7 articles (11/2010 - 01/2005)|
|3.||Saijo, Nagahiro: 5 articles (04/2013 - 08/2006)|
|4.||Macdougall, Iain C: 5 articles (03/2012 - 06/2003)|
|5.||Ohashi, Yasuo: 4 articles (04/2013 - 10/2006)|
|6.||Burger, Hans-Ulrich: 4 articles (11/2010 - 10/2006)|
|7.||Scherhag, A: 4 articles (12/2009 - 01/2006)|
|8.||Aapro, Matti: 4 articles (11/2009 - 01/2004)|
|9.||Osterborg, Anders: 3 articles (11/2012 - 05/2002)|
|10.||Coiffier, Bertrand: 3 articles (11/2012 - 08/2003)|
05/15/2002 - "Transfusion-free (P =.0012) survival and transfusion- and severe anemia-free survival (P =.0001) were significantly greater in the epoetin beta group versus placebo (Wald chi(2) test), giving a relative risk reduction of 43% and 51%, respectively. "
09/01/2001 - "Epoetin beta is shown to be safe and effective for the treatment of anemia in many patients with HRPC. "
01/01/2003 - "To assess the tolerability, safety and efficacy of the epoetin beta multidose cartridge formulation, self-administered subcutaneously via a pen device (Reco-Pen), in adult patients with renal anemia. "
12/01/2009 - "One of the larger trials to study the effects of complete correction of anemia in stages 3 to 4 CKD was the Cardiovascular Risk Reduction by Early Anemia Treatment with Epoetin Beta (CREATE) trial. "
12/01/2008 - "Using a fixed weekly dose of 3000 or 6000 IU of epoetin-beta, this study evaluated maintenance of improvement of anemia by comparing Hb concentration in the study period (once-weekly) with Hb concentration in the prestudy period (2 or 3 times per week). "
01/01/2004 - "The contribution of epoetin beta to the management of cancer-related anaemia over the past decade has been a significant one; increased haemoglobin (Hb) levels, reduced transfusion need and improved patient quality of life (QoL) have been well documented in patients across a wide range of malignancies. "
01/01/2004 - "These results suggest that treatment of anaemic patients with cancer with epoetin beta is effective and safe."
07/08/2008 - "Effect of treatment with epoetin-beta on survival, tumour progression and thromboembolic events in patients with cancer: an updated meta-analysis of 12 randomised controlled studies including 2301 patients."
06/01/2008 - "This once-weekly regimen is generally well tolerated, and studies to date have reported that epoetin beta has a neutral effect on survival of patients with cancer. "
05/01/2008 - "This study shows that epoetin beta rapidly, effectively, and safely increases Hb levels in patients with cervical cancer receiving RCT. "
09/13/2003 - "IMPROVED QUALITY OF LIFE WITH EPOETIN BETA: In a study against a placebo, there was evidence that the quality of life scores were significantly improved in patients treated with epoetin beta, whether they exhibited a solid tumour or a malignant lymphoma. "
08/01/2003 - "Patients with relapsed lymphoma undergoing aggressive chemotherapy and stem cell support benefited from epoetin beta therapy, with a decrease of RBC transfusion requirements and lower rise of fatigue levels."
08/01/2003 - "Recombinant human erythropoietin, epoetin beta, in patients with relapsed lymphoma treated with aggressive sequential salvage chemotherapy--results of a randomized trial."
04/01/2013 - "A total of 511 patients with solid tumor or lymphoma (epoetin beta or darbepoetin alfa, n = 273; placebo, n = 238) were included. "
08/01/2003 - "The aim of the study was to investigate the effects of erythropoietin (epoetin beta) on red blood cell (RBC) transfusions, hemoglobin (Hb) levels, and quality of life (QOL) in patients with relapsed lymphoma treated with an aggressive sequential salvage chemotherapy (SSCT) regimen. "
07/01/2008 - "The percentage of individuals perceiving moderate or important pain was significantly greater with darbepoetin-alpha (38%) compared with epoetin-beta (5%, p = 0.0005) and placebo (14%). "
07/01/2008 - "The aim of this study was to compare local pain experienced with subcutaneous (s.c.) injection of epoetin-beta vs. darbepoetin-alpha. "
12/01/2006 - "The patients perceived more intense immediate injection pain with darbepoetin-alpha than with epoetin-beta (5.4 +/- 1 vs 2.3 +/- 0.6, P < 0.05). "
12/01/2006 - "Increased injection pain with darbepoetin-alpha compared to epoetin-beta in paediatric dialysis patients."
01/01/1992 - "Pain scores were 1.12 +/- 0.28 versus 0.15 +/- 0.06 (p less than 0.05) and 1.75 +/- 0.19 versus 0.08 +/- 0.04 for epoetin-alpha and epoetin-beta, respectively (p less than 0.001). "
|5.||Renal Insufficiency (Renal Failure)
09/01/1995 - "Regarding the entire study population, there was no acceleration of the progression of renal failure during epoetin beta treatment nor were there any notable changes in laboratory values other than retention values. "
01/01/2003 - "Tolerability and efficacy of multidose epoetin beta (Reco-Pen) for subcutaneous administration in patients with anemia due to renal failure."
12/01/2009 - "Using four large trials [US Normal Hematocrit, Canadian European Normalization of Hemoglobin, Cardiovascular Risk Reduction by Early Anemia Treatment with Epoetin Beta (CREATE) and Correction of Hemoglobin and Outcomes in Renal Insufficiency (CHOIR)], this review article highlights several methodological issues that may be important when trial evidence is translated into clinical practice. "
09/01/2008 - "Recently, two large-scaled randomized controlled trials were reported, being the CREATE (cardiovascular risk reduction by early anemia treatment with epoetin beta) study and the CHOIR (correction of hemoglobin and outcomes in renal insufficiency) study. "
03/01/2009 - "Calls by Congress for Medicare to constrain ESA costs and FDA relabeling of erythropoietic-stimulating agents (ESAs), in the wake of The Correction of Hemoglobin and Outcomes in Renal Insufficiency and The Cardiovascular risk Reduction by Early Anemia Treatment with Epoetin Beta trials, have in 2007 led to the first decrease in mean hemoglobin levels in US hemodialysis patients since EPO was introduced in 1989. "
|2.||Polyethylene Glycols (Polyethylene Glycol)
|4.||darbepoetin alfa (Aranesp)
|6.||continuous erythropoietin receptor activator
|8.||Granulocyte Colony-Stimulating Factor (G-CSF)
|1.||Drug Therapy (Chemotherapy)
|2.||Renal Dialysis (Hemodialysis)
|4.||Transplantation (Transplant Recipients)