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TAC 363
structure given in first source
Also Known As:
N(alpha)-(tert-butylcarbamoyl)-L-glutaminyl-L-tryptophyl-alpha-aza-phenylalanine 2-benzyloxyethylamide; TAC-363
Networked:
1
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Oligopeptides: 519
TAC 363: 1
Related Diseases
1.
Asthma (Bronchial Asthma)
01/01/1997 - "
Thus, TAC-363 is expected to be useful in the treatment of airway diseases such as asthma.
"
2.
Respiratory Hypersensitivity
01/01/1997 - "
In summary, TAC-363 inhibits bronchoconstriction and airway hyperresponsiveness induced by various stimuli.
"
01/01/1997 - "
[Effect of a novel tachykinin NK-2-receptor antagonist, TAC-363, on bronchoconstriction and airway hyperresponsiveness in guinea pigs].
"
01/01/1997 - "
Furthermore, TAC-363 prevented the occurrence of capsaicin- and antigen-induced airway hyperresponsiveness to acetylcholine, while FK-888 did not prevent occurrence of capsaicin-induced airway hyperresponsiveness.
"
01/01/1997 - "
NKA-induced airway hyperresponsiveness to acetylcholine was attenuated by i.v. injection of TAC-363, but not by the thromboxane A2 synthetase inhibitor ozagrel and the mast cell stabilizer DSCG.
"
01/01/1997 - "
We examined the effect of a novel tachykinin NK-2-receptor antagonist, N alpha-(tert-Butylcarbamoyl)-L-glutaminyl-L-tryptophyl-alpha-aza- phenylalanine 2-benzyloxyethylamide (TAC-363), on hyperventilation- and citric acid-induced bronchoconstriction and neurokinin A (NKA)-, capsaicin- and antigen-induced airway hyperresponsiveness in guinea pigs.
"
3.
Hyperventilation
01/01/1997 - "
The i.v. administration of TAC-363 at doses of 0.01-1 mg/kg inhibited hyperventilation- and citric acid-induced bronchoconstriction in a dose-dependent manner, while FK-888, a tachykinin NK-1-receptor antagonist, did not inhibit hyperventilation-induced bronchoconstriction.
"
01/01/1997 - "
We examined the effect of a novel tachykinin NK-2-receptor antagonist, N alpha-(tert-Butylcarbamoyl)-L-glutaminyl-L-tryptophyl-alpha-aza- phenylalanine 2-benzyloxyethylamide (TAC-363), on hyperventilation- and citric acid-induced bronchoconstriction and neurokinin A (NKA)-, capsaicin- and antigen-induced airway hyperresponsiveness in guinea pigs.
"
Related Drugs and Biologics
1.
Citric Acid (Citrate)
2.
Tachykinins
3.
Neurokinin A
4.
Thromboxane-A Synthase
5.
Capsaicin (Zostrix)
6.
Antigens
7.
Acetylcholine (Acetylcholine Chloride)
8.
Mast Cell Stabilizers
9.
FK 888
10.
ozagrel