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Ro 60-0175

a 5HT 2C receptor agonist

Also Known As:

2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine fumarate; EP 655440-A; EP-655440-A; Ro-60-0175

Networked: 7 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - Ro 60-0175: 7
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Ro 60-0175: 7

Experts

1.	Beyeler, A: 1 article (08/2010)
2.	Boujema, M Ben: 1 article (08/2010)
3.	De Deurwaerdère, P: 1 article (08/2010)
4.	Gonon, F: 1 article (08/2010)
5.	Gross, C: 1 article (08/2010)
6.	Kadiri, N: 1 article (08/2010)
7.	Moine, C Le: 1 article (08/2010)
8.	Navailles, S: 1 article (08/2010)
9.	Centurión, David: 1 article (03/2002)
10.	Ortiz, Mario I: 1 article (03/2002)

Related Diseases

1.	Dyskinesias (Dyskinesia) 08/11/2010 - "In the present study, we combined behavioral, immunohistochemical and extracellular single-cell recordings approaches in rats to investigate the effect of the 5-HT(2C) agonist Ro-60-0175 respectively on orofacial dyskinesia, the expression of the marker of neuronal activity c-Fos in basal ganglia and the electrophysiological activity of substantia nigra pars reticulata (SNr) neuron connected to the orofacial motor cortex (OfMC) or the medial prefrontal cortex (mPFC). "
2.	Catalepsy 12/01/2000 - "In a final series of studies to examine the cataleptogenic properties of Ro 60-0175, very mild indices of catalepsy were observed at the 3 mg/kg dose only. "
3.	Body Weight (Weight, Body) 07/01/2000 - "5. These data suggest tolerance does not develop to the effects of d-fenfluramine, mCPP and Ro 60-0175 on rat body weight gain." 07/01/2000 - "Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats." 07/01/2000 - "1. The aim of the study was to compare the effects of 14 day subcutaneous infusion of the 5-HT(2C) receptor agonists, m-chlorophenylpiperazine (mCPP, 12 mg kg(-1) day(-1)) and Ro 60-0175 (36 mg kg(-1) day(-1)) and the 5-HT releasing agent and re-uptake inhibitor, d-fenfluramine (6 mg kg(-1) day(-1)), on food and water intake, body weight gain and locomotion in lean male Lister hooded rats. "
4.	Panic Disorder (Panic Attack) 10/01/1998 - "Like the selective serotonin re-uptake inhibitor (SSRI) fluoxetine, high affinity selective agonists such as Ro 60-0175 and Ro 60-0332 have potent in vivo activity in animal models suggestive of therapeutic action against depression, obsessive-compulsive disorder (OCD) and panic disorders. " 08/01/1998 - "In this paradigm which has been validated as a simulation of acute anxiety with relevance to panic disorder, the selective activation of 5HT2C receptors by Ro 60-0175, Org 12962 or Ro 60-0332 induces effects analogous to those observed following benzodiazepine receptor activation by antipanic agents such as clonazepam or alprazolam or following non-selective and indirect 5HT receptor activation by fluoxetine. "
5.	Cocaine-Related Disorders (Cocaine Addiction) 02/01/2023 - "Evaluation of the 5-HT2C receptor drugs RO 60-0175, WAY 161503 and mirtazepine in a preclinical model of comorbidity of depression and cocaine addiction."

Related Drugs and Biologics

1.	5-HT2C Serotonin Receptor
2.	Serotonin (5 Hydroxytryptamine)
3.	Fenfluramine
4.	1-(3-chlorophenyl)piperazine
5.	Fluoxetine (Prozac)
6.	GABA-A Receptors (GABA(A) Receptor)
7.	Clonazepam (Rivotril)
8.	Alprazolam (Xanax)
9.	8,9- dichloro- 2,3,4,4a- tetrahydro- 1H- pyrazino(1,2- a)quinoxalin- 5(6H)- one

Related Therapies and Procedures

1.	Subcutaneous Infusions