PAK 104P

used for reversing multidrug resistance

Also Known As:

2-(4-(diphenylmethyl)-1- piperazinyl)ethyl 5-(4,6-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate P-oxide; PAK 104P trihydrochloride, (trans)-isomer; PAK 104P, (trans)-isomer; PAK-104P; PAK104P

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198

Experts

1.	Garnier-Suillerot, Arlette: 1 article (01/2002)
2.	Kouyoumdjian, Jean Claude: 1 article (01/2002)
3.	Moretti, Jean Luc: 1 article (01/2002)
4.	Vergote, Jackie: 1 article (01/2002)
5.	Aikou, T: 1 article (01/2001)
6.	Akiyama, S: 1 article (01/2001)
7.	Furukawa, T: 1 article (01/2001)
8.	Ikeda, R: 1 article (01/2001)
9.	Kitazono, M: 1 article (01/2001)
10.	Nagayama, S: 1 article (01/2001)

Related Diseases

1.	Sarcoma (Soft Tissue Sarcoma) 02/01/1996 - "In the present study, the modulatory activity of the novel pyridine analogue PAK-104P on MRP-mediated resistance to doxorubicin and paclitaxel was investigated in two doxorubicin-selected human tumor cell lines [HT1080/DR4 (sarcoma) and HL60/ADR (leukemia)] and compared with the nonimmunosuppressive cyclosporine analogue PSC-833. "
2.	Leukemia 02/01/1996 - "In the present study, the modulatory activity of the novel pyridine analogue PAK-104P on MRP-mediated resistance to doxorubicin and paclitaxel was investigated in two doxorubicin-selected human tumor cell lines [HT1080/DR4 (sarcoma) and HL60/ADR (leukemia)] and compared with the nonimmunosuppressive cyclosporine analogue PSC-833. "
3.	Neoplasms (Cancer) 01/01/2001 - "PAK-104P may be useful for reversing MDR in tumors that overexpress LRP." 01/01/2002 - "MRP1 modulation by PAK-104P: detection with technetium-99m-MIBI in cultured lung tumor cells." 12/01/1999 - "CsA and PAK-104P may be useful for reversing cMOAT-mediated drug resistance in tumors." 05/01/1999 - "These findings suggest that MRP transports CPT-11 and SN-38 and is involved in resistance to CPT-11 and SN-38 and that PAK-104P reverses the resistance to CPT-11 and SN-38 in tumors that overexpress MRP."

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Cyclosporine (Ciclosporin)
3.	Doxorubicin (Adriamycin)
4.	valspodar (PSC 833)
5.	pyridine
6.	Multidrug Resistance-Associated Protein 2
7.	Irinotecan (Camptosar)
8.	multidrug resistance-associated protein 1