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malagashanine

from Strychnos sp.; structure given in first source

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - malagashanine: 5

Experts

1.	Rafatro, H: 2 articles (09/2000 - 05/2000)
2.	Rasoanaivo, P: 2 articles (09/2000 - 05/2000)
3.	Ramanitrahasimbola, David: 1 article (03/2006)
4.	Rasoanaivo, Philippe: 1 article (03/2006)
5.	Ratsimamanga, Suzanne: 1 article (03/2006)
6.	Vial, Henri: 1 article (03/2006)
7.	De Jonghe, P J: 1 article (09/2000)
8.	Gougnard, T Y: 1 article (09/2000)
9.	Laurent, A: 1 article (09/2000)
10.	Lhoëst, G: 1 article (09/2000)

Related Diseases

1.	Malaria 05/01/2000 - "Reversal activity of the naturally occurring chemosensitizer malagashanine in Plasmodium malaria." 09/01/2000 - "Malagashanine has been isolated from indigenous madagascan Strychnos myrtoides alkaloids used traditionally to treat malaria. " 03/01/2006 - "Malagashanine potentiates chloroquine antimalarial activity in drug resistant Plasmodium malaria by modifying both its efflux and influx."
2.	Cardiotoxicity 11/01/1999 - "Malagashanine alone was devoid of cytotoxicity and cardiac effect on isolated auricle, and importantly, when combined to chloroquine, did not affect the inherent toxicity and cardiac toxicity of this antimalarial agent."
3.	Parasitemia 07/01/1996 - "These two alkaloids are devoid of intrinsic antimalarial effects, both in vitro (IC50 = 73.0 micrograms/ml for strychnobrasiline and 69.1 micrograms/ml for malagashanine) and in vivo (10 mg/kg conferred a 5% suppression of parasitemia). "
4.	Acute malaria 05/01/2000 - "Malagashanine (MG) is the parent compound of a new type of indole alkaloids, the N(b)C(21)-secocuran, isolated so far from the Malagasy Strychnos species traditionally used as chloroquine adjuvants in the treatment of chronic malaria. "

Related Drugs and Biologics

1.	Chloroquine (Aralen)
2.	Antimalarials (Antimalarial Agents)
3.	Alkaloids
4.	Indole Alkaloids
5.	strychnobrasiline