|1.||Lazdunski, Michel: 8 articles (01/2013 - 06/2002)|
|2.||Lesage, Florian: 5 articles (03/2014 - 08/2004)|
|3.||Schwingshackl, Andreas: 4 articles (04/2015 - 01/2012)|
|4.||Xie, Minjie: 4 articles (09/2014 - 02/2012)|
|5.||Wang, Wei: 4 articles (09/2014 - 02/2012)|
|6.||Yu, Zhiyuan: 4 articles (09/2014 - 02/2012)|
|7.||Buxton, Iain L O: 3 articles (11/2015 - 06/2011)|
|8.||Teng, Bin: 3 articles (11/2014 - 01/2012)|
|9.||Ghosh, Manik: 3 articles (11/2014 - 01/2012)|
|10.||Waters, Christopher M: 3 articles (11/2014 - 01/2012)|
|1.||Acute Lung Injury
02/01/2012 - "In this study, we examined the expression of TREK-1 in rat brain under physiological and focal ischemia conditions. "
09/01/2014 - "LIN is a potent activator of TREK-1 channel and LIN-induced neuroprotection disappears in Trek1-/- mice, suggesting that this channel is directly related to the LIN-induced resistance of brain against ischemia. "
08/01/2014 - "It seems that TREK-1 is a potential drug target for treatment of acute heart ischemia."
03/01/2013 - "Involvement of TREK-1 activity in astrocyte function and neuroprotection under simulated ischemia conditions."
02/01/2012 - "These data provide evidence showing the astrocytic TREK-1 involvement in ischemia pathology."
01/01/2012 - "In this study we hypothesized that hyperoxia affects expression of Trek-1 in alveolar epithelial cells and that Trek-1 is involved in regulation of cell proliferation and cytokine secretion. "
01/01/2012 - "This is the first report suggesting that the K(+) channel Trek-1 could be involved in regulation of alveolar epithelial cell proliferation and cytokine secretion, but a direct association with hyperoxia-induced changes in Trek-1 levels remains elusive."
01/01/2012 - "Overall, deficiency of Trek-1 had a more pronounced effect on mediator secretion than exposure to hyperoxia. "
01/01/2012 - "We found gene expression of several K2P channels in mouse alveolar epithelial cells (MLE-12), and expression of Trek-1 was significantly downregulated in cultured cells and lungs of mice exposed to hyperoxia. "
11/01/2014 - "In this study, we focused on investigating the role of TREK-1 in vivo in the development of hyperoxia-induced lung injury. "
|4.||Prostatic Neoplasms (Prostate Cancer)
07/30/2015 - "In this study, we assessed the expression of TREK-1 in 100 prostate cancer (PCa) tissues using immunohistochemistry and further analyzed its clinicopathological significance. "
02/15/2008 - "In vitro studies showed that TREK-1 is highly expressed in PC3 and LNCaP prostate cancer cell lines but is not detectable in normal prostate epithelial cells (NPE). "
02/15/2008 - "Taken together, these data suggest that TREK-1 expression is associated with abnormal cell proliferation and may be a novel marker for and a molecular target in prostate cancer."
02/15/2008 - "TREK-1 is a novel molecular target in prostate cancer."
07/30/2015 - "Prognostic significance of the TREK-1 K2P potassium channels in prostate cancer."
03/21/2014 - "It has been reported that TREK-1 -/- mice were more sensitive than wild-type mice to painful stimuli, suggesting that activation of TREK-1 could result in pain inhibition. "
05/06/2009 - "TRAAK and TREK-1 channels control pain produced by mechanical stimulation and both heat and cold pain perception in mice. "
01/01/2011 - "TREK-1 potassium channels are involved in a number of physiopathological processes such as neuroprotection, pain and depression. "
11/01/2008 - "The heat-, stretch- and lipid-activated TREK-1 channels contribute to temperature and mechanical pain sensation, neuroprotection by polyunsaturated fatty acids and, unexpectedly, mood regulation. "
01/01/2012 - "In this study we showed that spadin did not interfere with other TREK-1 controlled functions such as pain, epilepsy and ischemia. "
|1.||Potassium Channels (Potassium Channel)
|2.||Messenger RNA (mRNA)
|3.||Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)
|4.||Arachidonic Acid (Vitamin F)
|6.||Glutamic Acid (Glutamate)
|10.||Nitrous Oxide (Laughing Gas)