potassium channel protein TREK-1

a mammalian TWIK-1-related potassium channel; amino acid sequence given in first source; GenBank U73488; RefSeq NM_014217 (human), NM_010607 (mouse), NM_172041-2 (rat)

Also Known As:

KCNK2 protein; KCNK2 protein, human; Kcnk2 protein, mouse; Kcnk2 protein, rat; TREK protein; TREK protein, human; TREK-1; TREK-1 potassium channel; TREK-1 protein, human; TREK-1 protein, mouse; TREK1 protein; Trek-1 protein, rat; potassium channel, subfamily K, member 2 protein, human; potassium channel, subfamily K, member 2 protein, mouse; potassium channel, subfamily K, member 2 protein, rat

Networked: 114 relevant articles (6 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Potassium Channels: 2882
        Tandem Pore Domain Potassium Channels: 9
        potassium channel protein TREK-1: 114
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Ion Channels: 6731
        Potassium Channels: 2882
        Tandem Pore Domain Potassium Channels: 9
        potassium channel protein TREK-1: 114
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Potassium Channels: 2882
        Tandem Pore Domain Potassium Channels: 9
        potassium channel protein TREK-1: 114

Experts

1.	Lazdunski, Michel: 9 articles (01/2018 - 06/2002)
2.	Wang, Wei: 8 articles (04/2022 - 02/2012)
3.	Schwingshackl, Andreas: 8 articles (01/2021 - 01/2012)
4.	Xie, Minjie: 7 articles (04/2022 - 02/2012)
5.	Lesage, Florian: 7 articles (12/2017 - 08/2004)
6.	Waters, Christopher M: 6 articles (12/2020 - 01/2012)
7.	Borsotto, Marc: 5 articles (11/2019 - 05/2009)
8.	Heurteaux, Catherine: 5 articles (11/2019 - 07/2007)
9.	Eschalier, Alain: 5 articles (01/2018 - 05/2009)
10.	Liu, Yang: 4 articles (04/2022 - 12/2012)

Related Diseases

1.	Lung Injury 01/01/2023 - "Therefore, TREK-1 activation may represent a novel therapeutic approach against IAV-induced lung injury." 04/15/2015 - "In the next section, we will address transcellular ion transport and highlight the role of Trek-1 in epithelial responses to lung injury. " 11/01/2014 - "In this study, we focused on investigating the role of TREK-1 in vivo in the development of hyperoxia-induced lung injury. " 12/15/2020 - "We treated HO-exposed mice and primary alveolar epithelial cells (AECs) with the novel TREK-1 activators ML335 and BL1249, and quantified physiological, histological, and biochemical lung injury markers. " 01/01/2023 - "Activation of TREK-1 (K2P2.1) potassium channels protects against influenza A-induced lung injury."
2.	Acute Lung Injury 02/15/2013 - "The results of this study identify Trek-1 as a new potential target for the development of novel treatment strategies against acute lung injury." 01/01/2021 - "We recently established a role for the stretch-activated two-pore-domain K+ (K2P) channel TREK-1 (K2P2.1) in inflammatory cytokine secretion using models of hyperoxia-, mechanical stretch-, and TNF-α-induced acute lung injury. "
3.	Stroke (Strokes) 11/01/2019 - "This work reveals the first evidence that the modulation of TREK-1 channels in the early and chronic phases of stroke as well as the stimulation of brain plasticity by mini-spadin could play a key role in its brain protective effects against stroke and its deleterious consequences such as PSD." 11/01/2019 - "The TREK-1 channel represents a crucial target in the pathogenesis of stroke and depression. " 09/01/2014 - "TREK-1 may serve as a promising multi-mechanism therapeutic target for the treatment of stroke. " 03/01/2013 - "This would provide evidence showing astrocytic TREK-1 involvement in ischemia pathology which may serve as a potential therapeutic target in stroke." 06/01/2015 - "TREK-1, a two-pore-domain potassium channel, has been implicated in the pathogenesis of stroke and depression. "
4.	Infarction (Infarctions) 04/01/2022 - "Finally, the specific pharmacological inhibition of TREK-1 also decreased infarction size and improved neurological function. " 10/01/2019 - "TREK-1 deficiency increased infarct size following permanent coronary artery ligation, resulting in greater systolic dysfunction than the WT counterpart. " 11/01/2011 - "TREK-1 mRNA expression decreased significantly in both endocardial and epicardial cells in the infarct region after MI. " 11/01/2011 - "TREK-1 messenger RNA (mRNA) expression level in the infarct region (IR) and infarct border region (IBR) were quantified by real-time polymerase chain reaction (PCR), and TREK-1 current density at the IBR was recorded with whole-cell patch-clamp technique. "
5.	Memory Disorders (Memory Loss) 03/01/2020 - "These altered synaptic transmission and plasticity are associated with recognition memory deficit in TREK-1 KO mice. " 08/01/2022 - "α-Linolenic acid (ALA), an activator of the TREK-1 channel, significantly increased the TREK-1 level, and improved the learning and memory deficits of SAMP8 mice aged 6 months. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Glutamic Acid (Glutamate)
3.	(5,6,7,8- tetrahydronaphthalen- 1- yl)- (2- (1H- tetrazol- 5- yl)phenyl)amine
4.	alpha-Linolenic Acid (Linolenic Acid)
5.	Interleukin-6 (Interleukin 6)
6.	Potassium Channels (Potassium Channel)
7.	Neuroprotective Agents
8.	Sevoflurane (Ultane)
9.	Cytokines
10.	Formaldehyde (Formol)

Related Therapies and Procedures

1.	Ligation
2.	Anesthesia
3.	Therapeutics
4.	Spinal Injections
5.	Analgesia