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sulforamate

an analog of sulforaphane; structure given in first source

Also Known As:

4-methylsulfinyl-1-(S-methyldithiocarbamyl)butane

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Carbamates: 945
      - Thiocarbamates: 27
        sulforamate: 3
- Sulfur Compounds: 278
  - Thiocarbamates: 27
    - sulforamate: 3

Experts

1.	Kosmeder, Jerome: 1 article (01/2006)
2.	Moriarty, Robert M: 1 article (01/2006)
3.	Naithani, Rajesh: 1 article (01/2006)
4.	Prakash, Om: 1 article (01/2006)
5.	Park, Eun Jung: 1 article (01/2002)
6.	Pezzuto, John M: 1 article (01/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2006 - "Cancer chemopreventive activity of sulforamate derivatives." 01/15/1997 - "Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes." 01/15/1997 - "We currently report the synthesis and activity of a novel cancer chemopreventive agent, (+/-)-4-methylsulfinyl-1-(S-methyldithiocarbamyl)-butane (trivial name, sulforamate), an aliphatic analogue of brassinin with structural similarities to sulforaphane. " 01/01/2002 - "Several lead compounds, such as brassinin (from cruciferous vegetables like Chinese cabbage), sulforaphane (from broccoli) and its analog sulforamate, withanolides (from tomatillos), and resveratrol (from grapes and peanuts among other foods), are in preclinical or clinical trials for cancer chemoprevention. "
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/2006 - "In the present studies we have synthesized several derivatives of (+)(-) 4-methylsulfinyl-1-(S-methyldithiocarbamyl)-butane (sulforamate) and evaluated their effectiveness as monofunctional inducer of the NAD(P)H Quinone oxidoreductase [quinone reductase (QR)] a phase II enzyme in cultured Hepa1c1c7 murine hepatoma cells. "

Related Drugs and Biologics

1.	Enzymes
2.	brassinin
3.	sulforaphane
4.	Withanolides
5.	NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)
6.	Oxidoreductases (Dehydrogenase)
7.	NAD (NADH)
8.	Resveratrol
9.	quinone (benzoquinone)
10.	butane

Related Therapies and Procedures

1.	Chemoprevention