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3-amino-1-methylpyrrolidin-2-ol

structure in first source

Also Known As:

3-amino-2-hydroxy-1-methylpyrrolidine; CFSUM1; aminohydroxy-N-methylpyrrolidine

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - 3-amino-1-methylpyrrolidin-2-ol: 4

Experts

1.	Amjad, Saira: 1 article (02/2006)
2.	Chalmers, Ronald A: 1 article (02/2006)
3.	Goodwin, C Stewart: 1 article (02/2006)
4.	Jones, Mark G: 1 article (02/2006)
5.	Butt, Henry L: 1 article (01/2003)
6.	Dunstan, R Hugh: 1 article (01/2003)
7.	Klineberg, Iven J: 1 article (01/2003)
8.	McGregor, Neil R: 1 article (01/2003)
9.	Niblett, Suzanne H: 1 article (01/2003)
10.	Roberts, Timothy K: 1 article (01/2003)

Related Diseases

1.	Chronic Fatigue Syndrome (Myalgic Encephalomyelitis) 02/01/2006 - "McGregor et al. reported increased levels of an unidentified urinary compound (CFSUM1) in patients with chronic fatigue syndrome (CFS), with reduced excretion of another unidentified compound (CFSUM2), and suggested the possibility of chemical or metabolic 'markers' for CFS. " 02/01/2006 - "CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts." 06/01/1996 - "Chronic fatigue syndrome (CFS) patients have a urinary metabolite labeled CFSUM1 with increased incidence (P < 0.004) and relative abundance (P < 0.00003). "
2.	Fatigue 06/01/1996 - "Severe fatigue was the only symptom with 100% sensitivity and specificity and CFSUM1 excretion was the primary metabolite for expression of this symptom. " 04/01/1996 - "The CFS patients had increases in aminohydroxy-N-methylpyrrolidine (P < 0.00003, referred to as chronic fatigue symptom urinary marker 1, or CFSUM1), tyrosine (P < 0.02), beta-alanine (P < 0.02), aconitic acid (P < 0.05), and succinic acid (P < 0.05) and reductions in an unidentified urinary metabolite, CFSUM2 (P < 0.0007), alanine (P < 0.005), and glutamic acid (P < 0.02). "
3.	Pain (Aches) 01/01/2003 - "Pain intensity was associated with: (1) changes in the multivariate urinary metabolite excretion patterns (P < .001); (2) reduced leucine concentrations (P < .001); and (3) increases in total urinary metabolites (P < .04), and in 2 unidentified molecules, UM28 (P < .001) and CFSUM1 (P < .002). "
4.	Infections 06/01/1996 - "CFSUM1 and beta-alanine were the first and second metabolites correlated with the CFS core symptom index and CFSUM1 was primarily associated with infection-related and musculoskeletal indices whereas beta-alanine was primarily associated with gastrointestinal and genitourinary indices. "

Related Drugs and Biologics

1.	beta-Alanine
2.	3-amino-1-methylpyrrolidin-2-ol
3.	Succinic Acid (Succinate)
4.	Glutamic Acid (Glutamate)
5.	Tyrosine (L-Tyrosine)
6.	Leucine (L-Leucine)
7.	Alanine (L-Alanine)
8.	Aconitic Acid (Aconitate)