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S-mephenytoin N-demethylase (CYP2B6)

liver cytochrome P-450 enzyme that catalyzes the N-demthylation of S-mephenytoin; substrates include a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; inducible by phenobarbital
Also Known As:
CYP2B6; CYP2B6 protein, human; CYPIIB6; CYPIIB6 protein, human; Cyp2b6 protein, rat; cytochrome P-450 CYP2B6; cytochrome P-450 CYP2B6 (human); cytochrome P-450 CYP2B6 (rabbit); cytochrome P-450 CYP2B6, human; cytochrome P450, family 2, subfamily B, polypeptide 6, human; cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6, rat; mephenytoin demethylase
Networked: 134 relevant articles (5 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Haas, David W: 5 articles (12/2015 - 07/2006)
2. Dandara, Collet: 5 articles (09/2015 - 08/2013)
3. Swart, Marelize: 4 articles (09/2015 - 08/2013)
4. Sukasem, Chonlaphat: 4 articles (01/2014 - 12/2012)
5. Zanger, Ulrich M: 4 articles (05/2013 - 07/2006)
6. Nhachi, Charles: 3 articles (01/2015 - 04/2008)
7. Masimirembwa, Collen: 3 articles (01/2015 - 04/2008)
8. Acosta, Edward P: 3 articles (08/2014 - 09/2010)
9. Morse, Gene D: 3 articles (08/2014 - 09/2010)
10. Manosuthi, Weerawat: 3 articles (01/2014 - 01/2013)

Related Diseases

1. Breast Neoplasms (Breast Cancer)
2. Chronic Kidney Failure (Chronic Renal Failure)
3. Anoxia (Hypoxia)
4. Lymphoma (Lymphomas)
5. Autoimmune Diseases (Autoimmune Disease)

Related Drugs and Biologics

1. Cytochrome P-450 CYP2D6 (CYP2D6)
2. Cytochrome P-450 CYP1A2 (CYP1A2)
3. Cytochrome P-450 CYP1A1 (CYP1A1)
4. Cytochrome P-450 CYP2E1 (CYP2E1)
5. Cytochrome P-450 CYP3A
6. Thiotepa (Triethylenethiophosphoramide)
7. docetaxel (Taxotere)
8. Tamoxifen
9. cytochrome P-450 CYP3A6 (rabbit)
10. efavirenz (Sustiva)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Subcutaneous Infusions
3. Lasers (Laser)
4. Combination Drug Therapy (Combination Chemotherapy)