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deoxythymidine diphosphate-glucose

structure given in first source

Also Known As:

dTDP-glucose

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kuzminov, Andrei: 1 article (12/2020)
2.	Rao, T V Pritha: 1 article (12/2020)
3.	Brown, Haley A: 1 article (01/2018)
4.	Holden, Hazel M: 1 article (01/2018)
5.	Thoden, James B: 1 article (01/2018)
6.	Tipton, Peter A: 1 article (01/2018)
7.	Frey, Perry A: 1 article (02/2002)
8.	Gross, Jeffrey W: 1 article (02/2002)
9.	Hegeman, Adrian D: 1 article (02/2002)
10.	Frey, P A: 1 article (10/2001)

Related Diseases

1.	Starvation 12/29/2020 - "The thyA mutant, in which dTDP-glucose production is blocked by the rfbA rffH mutations, lacks a LMW-dT pool, the initial DNA synthesis during T-starvation and the resistance phase. " 12/01/1975 - "In a thymine-deprived culture, the mutant cells (deficient in dTDP-glucose pyrophosphorylase activity and named Ter-15) lose viability at a faster rate, form longer filaments for the first 60 min and lose thymidine nucleotides and dTDP-sugar pools at a faster rate for the first 15 min than those of the parent cells, but the dTDP-sugar pool in the parent cells is maintained at high concentration for the first 90 min during thymine starvation. "
2.	Dehydration (Water Stress) 02/26/2002 - "The conversion of dTDP-glucose into dTDP-4-keto-6-deoxyglucose by Escherichia coli dTDP-glucose 4,6-dehydratase (4,6-dehydratase) takes place in the active site in three steps: dehydrogenation to dTDP-4-ketoglucose, dehydration to dTDP-4-ketoglucose-5,6-ene, and rereduction of C6 to the methyl group. " 02/26/2002 - "Concerted and stepwise dehydration mechanisms observed in wild-type and mutated Escherichia coli dTDP-glucose 4,6-dehydratase." 10/23/2001 - "The dTDP-glucose 4,6-dehydratase catalyzed conversion of dTDP-glucose to dTDP-4-keto-6-deoxyglucose occurs in three sequential chemical steps: dehydrogenation, dehydration, and rereduction. " 10/23/2001 - "Dehydration is catalyzed by glutamate-136 and aspartic acid-135 active site residues in Escherichia coli dTDP-glucose 4,6-dehydratase."
3.	Tuberculosis (Tuberculoses) 01/01/2018 - "tuberculosis RmlA in complex with either dTTP or dTDP-glucose to 1.6 Å and 1.85 Å resolution, respectively. "

Related Drugs and Biologics

1.	Thymine
2.	Thymidine
3.	Nucleotides
4.	DNA (Deoxyribonucleic Acid)
5.	Sugars
6.	thymidine 5'-triphosphate (thymidine triphosphate)