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3- (3- (dimethylamino)propyl)- 4- hydroxy- N- (4- (4- pyridinyl)phenyl)benzamide

a 5-HT(1D) receptor antagonist; RN given refers to HCl salt

Also Known As:

GR 55562; GR-55562; GR55562

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Haag, M M: 1 article (01/2019)
2.	Lavoie, B: 1 article (01/2019)
3.	Lian, J B: 1 article (01/2019)
4.	Margolis, K G: 1 article (01/2019)
5.	Mawe, G M: 1 article (01/2019)
6.	Roberts, J A: 1 article (01/2019)
7.	Sharkey, K A: 1 article (01/2019)
8.	Spohn, S N: 1 article (01/2019)
9.	An, C-H: 1 article (09/2012)
10.	Cho, J-H: 1 article (09/2012)

Related Diseases

1.	Serotonin Syndrome (Syndrome, Serotonin) 06/01/2005 - "Pretreatment with the 5HT 1A receptor antagonist, WAY 100635 (1 mg/kg), prevented MDMA-induced increases in social interaction and markers of the serotonin syndrome while the 5-HT 1B receptor antagonist GR 55562 (1 mg/kg) and 5-HT 2A receptor antagonist ketanserin (1 mg/kg) were ineffective. "
2.	Migraine Disorders (Migraine) 09/01/2012 - "Sumatriptan, an anti-migraine drug, also decreased EPSC amplitude, and this effect was partially blocked by either GR55562 or LY310762. "
3.	Hypothermia 02/01/2008 - "Aspirin plus GR55562 had a greater effect on LPS-induced digital hypothermia than aspirin alone. "
4.	Hyperglycemia 05/01/2000 - "Finally, ketanserin (a 5-HT(2A) receptor antagonist), but not p-MPPF (a 5-HT(1A) receptor antagonist), GR 55562 (a 5-HT(1B/1D) receptor antagonist), SB 206553 (a 5-HT(2B/2C) receptor antagonist), or tropisetron (a 5-HT(3) receptor antagonist), was able to block 5-HT-induced hyperglycemia. "
5.	Colitis 01/01/2019 - "The colitis-induced loss of trabecular bone was significantly suppressed in mice treated with the 5-HT synthesis inhibitor, p-chloro-DL-phenylalanine (PCPA; 300 mg/kg/day IP daily), and in mice treated with the 5-HT1B receptor antagonist GR55562 (1 mg/Kg/day SC daily). "

Related Drugs and Biologics

1.	Serotonin (5 Hydroxytryptamine)
2.	Ketanserin
3.	5-HT1B Serotonin Receptor
4.	N-Methyl-3,4-methylenedioxyamphetamine (MDMA)
5.	Sumatriptan (Imigran)
6.	Phenylalanine (L-Phenylalanine)
7.	Aspirin (Acetylsalicylic Acid)
8.	Tropisetron (Navoban)
9.	1- (2- (4- (4- fluoro- benzoyl)- piperidin- 1- yl)- ethyl)- 3,3- dimethyl- 1,2- dihydro- indol- 2- one
10.	4-(2' methoxyphenyl)- 1- (2'- (N- (2''- pyridinyl)- 4- fluorobenzamido)ethyl)piperazine