hispolon

11/04/2020 - "Our recent study has demonstrated hispolon as a potent apoptosis inducer in melanoma cell lines. "
09/01/2020 - "Thus, hispolon can be a potent anti-melanoma drug in the future if the pharmacodynamic effects and the toxicological studies are appropriately carried out."
01/17/2014 - "In this study, we analyzed the functions of hispolon on melanogenesis and apoptosis in B16-F10 melanoma cells. "
09/01/2020 - "Elucidating the anti-melanoma effect and mechanisms of Hispolon."
09/01/2020 - "Thus, our present study was to investigate the anti-cancer effect of hispolon on melanoma cancer cells. "

02/01/2016 - "The present study evaluated the anticancer potential of hispolon in TRAIL‑induced apoptosis and indicated hispolon can sensitize cancer cells to TRAIL. "
09/01/2019 - "Hispolon induces apoptosis against prostate DU145 cancer cells via modulation of mitochondrial and STAT3 pathways."
09/01/2019 - "Hispolon has been shown to possess antitumor effects in various cancer cells. "
01/01/2019 - "Hispolon is a polyphenolic compound derived from black hoof mushroom (Phellinus linteus) or shaggy bracket mushroom (Inonotus hispidus) which induces the inhibition of cancer-promoting nuclear factor-kappa beta (NF-κβ) complex. "
10/05/2017 - "Hispolon, a phenolic compound isolated from Phellinus igniarius, induces apoptosis and anti-tumor effects in cancers. "

07/01/2008 - "In this study, we investigated the efficacy of hispolon in human gastric cancer cells and explored the cell death mechanism. "
08/01/2009 - "Hispolon extracted from Phellinus species was found to induce epidermoid and gastric cancer cell apoptosis. "
07/01/2008 - "Furthermore, hispolon potentiated the cytotoxicity of chemotherapeutic agents used in the clinical management of gastric cancer. "
07/01/2008 - "Hispolon induced ROS-mediated apoptosis in gastric cancer cells and was more toxic toward gastric cancer cells than toward normal gastric cells, suggesting greater susceptibility of the malignant cells. "
07/01/2008 - "Hispolon induces apoptosis in human gastric cancer cells through a ROS-mediated mitochondrial pathway."

01/01/2013 - "We conclude that hispolon induces both of extrinsic and intrinsic apoptotic pathways in NB4 human leukemia cells in vitro. "
08/07/2015 - "In this latter context, Hispolon has been reported to exhibit therapeutic efficacy against various cancer cells, including melanoma, leukemia, hepatocarcinoma, bladder cancer, and gastric cancer cells. "

08/01/2009 - "Herein, we report our findings that hispolon inhibited breast and bladder cancer cell growth, regardless of p53 status. "
08/01/2009 - "Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells."
08/01/2009 - "In conclusion, hispolon ubiquitinates and downregulates MDM2 via MDM2-recruited activated ERK1/2. Therefore, hispolon may be a potential anti-tumor agent in breast and bladder cancers."
08/07/2015 - "In this latter context, Hispolon has been reported to exhibit therapeutic efficacy against various cancer cells, including melanoma, leukemia, hepatocarcinoma, bladder cancer, and gastric cancer cells. "