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poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer

structure given in first source
Also Known As:
PLGA-PEG copolymer; PLGA-b-PEG; poly(D,L-lactic-co-glycolic acid)-block-poly(ethylene glycol)
Networked: 13 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Farokhzad, Omid C: 6 articles (01/2015 - 04/2006)
2. Langer, Robert: 4 articles (01/2010 - 04/2006)
3. Dhar, Shanta: 3 articles (10/2012 - 11/2008)
4. Sekar, Thillai V: 2 articles (06/2015 - 03/2015)
5. Paulmurugan, Ramasamy: 2 articles (06/2015 - 03/2015)
6. Devulapally, Rammohan: 2 articles (06/2015 - 03/2015)
7. Lippard, Stephen J: 2 articles (02/2011 - 11/2008)
8. Poojari, Radhika: 1 article (11/2015)
9. Srivastava, Rohit: 1 article (11/2015)
10. Kini, Sudarshan: 1 article (11/2015)

Related Diseases

1. Neoplasms (Cancer)
03/24/2015 - "We synthesized the antisense-miR-21 and antisense-miR-10b loaded PLGA-b-PEG polymer NPs and evaluated their cellular uptake, serum stability, release profile, and the subsequent synchronous blocking of endogenous miR-21 and miR-10b function in TNBC cells in culture, and tumor xenografts in living animals using molecular imaging. "
10/02/2012 - "Considering efficacy, the targeted PLGA-b-PEG-TPP NP provides a remarkable improvement in the drug therapeutic index for cancer, Alzheimer's disease, and obesity compared with the nontargeted construct or the therapeutics in their free form. "
07/01/2011 - "Base on the above results, it can be concluded that PHis-b-PLGA-b-PEG-b-PLGA-b-PHis block copolymer micelles which respond to temperature and pH stimuli are promising smart carriers for anti-tumor drugs with the advantages of temperature- and pH- triggered drug release."
11/11/2008 - "A comparison between the cytotoxic activities of Pt(IV)-encapsulated PLGA-b-PEG NPs with the PSMA aptamer on the surface (Pt-NP-Apt), cisplatin, and the nontargeted Pt(IV)-encapsulated NPs (Pt-NP) against human prostate PSMA-overexpressing LNCaP and PSMA(-) PC3 cancer cells revealed significant differences. "
07/10/2015 - "Using the reaction of non-small cell lung cancer (SK-MES-1 and A549 cell lines) as representative of other cancer types', the present study examines the effects of EpCAM-fluoropyrimidine RNA aptamer-decorated, DOX-loaded, PLGA-b-PEG nanopolymersomes that bond specifically to the extracellular domain of epithelial-cell adhesion molecules. "
2. Obesity
3. Alzheimer Disease (Alzheimer's Disease)
4. Hepatocellular Carcinoma (Hepatoma)
5. Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)

Related Drugs and Biologics

1. Ethylene Glycol (Monoethylene Glycol)
2. polylactic acid-polyglycolic acid copolymer (PLGA)
3. RNA (Ribonucleic Acid)
4. combretastatin A-4 (combretastatin A4)
5. tumor-associated antigen GA733
6. 2-methoxyestradiol
7. human glutamate carboxypeptidase II
8. poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer
9. antineoplaston A10 (A 10)
10. Nucleotide Aptamers

Related Therapies and Procedures

1. Therapeutics
2. Heterologous Transplantation (Xenotransplantation)