BMAP-27

C-terminal domain of a cathelicidin, a myeloid antimicrobial peptide precursor; BMAP-27 stands for bovine myeloid antimicrobial peptide of 27 residues; amino acid sequence in first source; GenBank X97608

Networked: 8 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Pore Forming Cytotoxic Proteins
      - Antimicrobial Cationic Peptides: 414
        BMAP-27: 8
- Peptides: 82426
  - Antimicrobial Peptides: 3727
    - Antimicrobial Cationic Peptides: 414
      - BMAP-27: 8
  - Antimicrobial Cationic Peptides: 414
    - BMAP-27: 8

Experts

1.	Skerlavaj, Barbara: 3 articles (10/2017 - 11/2006)
2.	D'Este, Francesca: 2 articles (10/2017 - 04/2010)
3.	Tossi, Alessandro: 2 articles (10/2017 - 04/2010)
4.	Crocetta, Valentina: 2 articles (01/2016 - 07/2012)
5.	Di Bonaventura, Giovanni: 2 articles (01/2016 - 07/2012)
6.	Gennaro, Renato: 2 articles (01/2016 - 07/2012)
7.	Mardirossian, Mario: 2 articles (01/2016 - 07/2012)
8.	Pompilio, Arianna: 2 articles (01/2016 - 07/2012)
9.	Scocchi, Marco: 2 articles (01/2016 - 07/2012)
10.	Zanetti, Margherita: 2 articles (04/2010 - 11/2006)

Related Diseases

1.	Infections 03/09/2020 - "In this study, we compared the bactericidal activities, antibiofilm activities and immune-modulatory properties of cathelicidins BMAP-27, BMAP-34, mCRAMP, and LL-37, and evaluated the therapeutic efficacy of the combination of BMAP-27 and LL-37 using a mouse pulmonary infection model. " 10/01/2017 - "Peptides were effective at micromolar concentrations against 22 Staphylococcus and Streptococcus isolates from orthopaedic infections, while only BMAP-28 and to a lesser extent BMAP-27 were active against Enterococcus faecalis. " 10/01/2017 - "The aim of this study was to evaluate the potential of five different helical AMPs, the cathelicidins BMAP-27 and BMAP-28, their (1-18) fragments and the rationally designed, artificial P19(9/G7) peptide, for the prevention of orthopaedic implant infections. "
2.	Bovine Mastitis 04/01/2010 - "The aims of this study were to investigate the expression of the bovine cathelicidins BMAP-27, BMAP-28, Bac5, and indolicidin in healthy and infected mammary tissue and in lipopolysaccharide (LPS)-treated cells, to determine their activities against bacteria isolated from bovine mastitis, and to examine their potentials to trigger defense responses in bovine mammary cells. "
3.	Cystic Fibrosis (Mucoviscidosis) 01/01/2016 - "The alpha-helical antimicrobial peptides BMAP-27 and BMAP-28 have shown to be highly active in vitro against planktonic and sessile forms of multidrug-resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Stenotrophomonas maltophilia cystic fibrosis strains. " 07/23/2012 - "Three α-helical antimicrobial peptides, BMAP-27 and BMAP-28 of bovine origin, and the artificial P19(9/B) peptide were tested, comparatively to Tobramycin, for their in vitro antibacterial and anti-biofilm activity against 15 Staphylococcus aureus, 25 Pseudomonas aeruginosa, and 27 Stenotrophomonas maltophilia strains from cystic fibrosis patients. "
4.	Obstructive Jaundice (Cholestatic Jaundice) 11/01/2006 - "In light of its dual antimicrobial and anti-endotoxin properties, BMAP-27 could be an interesting compound to inhibit bacterial translocation and endotoxin release in obstructive jaundice." 11/01/2006 - "Effects of the antimicrobial peptide BMAP-27 in a mouse model of obstructive jaundice stimulated by lipopolysaccharide."
5.	Neoplasms (Cancer) 01/01/2019 - "While the N-terminal 18-residue peptide (BMAP-18) exerted only antibacterial activity, BMAP-27 showed potent activity against bacteria and cancer cells. "

Related Drugs and Biologics

1.	Cathelicidins
2.	BMAP-28
3.	Peptides (Polypeptides)
4.	Lipopolysaccharides
5.	indolicidin
6.	Antimicrobial Peptides
7.	Tobramycin (Nebcin)
8.	Endotoxins