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NNC 14-0189

structure given in first source

Also Known As:

3-(5-cyclopropyl-1,2,4-oxadiazol-3--yl)-7-fluoro-5-(4-methyl-1-piperazinyl)imidazol(1,5-a)quinazoline

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - NNC 14-0189: 2

Related Diseases

1.

Seizures (Absence Seizure)

11/01/1996 - "In one approach, mice were chronically treated with either NNC 14-0185 or NNC 14-0189 for 4 weeks at doses which were about equipotent to increase the threshold for myoclonic seizures induced by pentylenetetrazole. "
07/11/1996 - "The anticonvulsant effects of NNC 14-0185 and NNC 14-0189 against pentylenetetrazole-induced seizures were apparent within 5 min of i.p. "
07/11/1996 - "NNC 14-0185 and NNC 14-0189 prevented seizures induced by pentylenetetrazole in rats and were also effective anticonvulsants in amygdala-kindled rats. "
07/11/1996 - "administration, NNC 14-0185 and NNC 14-0189 prevented audiogenic seizures in DBA/2 mice and the clonic convulsions induced in mice by pentylenetetrazole, DMCM (methyl 6, 7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate), 3-mercaptopropionic acid and a low dose of bicuculline. "

Related Drugs and Biologics

1.	Pentylenetetrazole (Metrazol)
2.	NNC 14-0185
3.	3-Mercaptopropionic Acid (3 Mercaptopropionic Acid)
4.	Bicuculline
5.	Anticonvulsants (Antiepileptic Drugs)
6.	methyl 6,7- dimethoxy- 4- ethyl- beta- carboline- 3- carboxylate