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iodothyronine deiodinase type II

Type II iodothyronine deiodinase activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine; may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease, toxic adenomas, and, perhaps, iodine deficiency; RefSeq NM_000793 (human); NM_031720 (rat); NM_010050 (mouse)
Also Known As:
D2 protein, human; DIO2 protein, human; Dio2 protein, mouse; Dio2 protein, rat; TXDI2 protein, human; deiodinase iodothyronine type 2, rat; deiodinase, iodothyronine, type II, human; deiodinase, iodothyronine, type II, mouse; deiodinase, iodothyronine, type II, rat; hdio2 protein, human; iodothyronine type II deiodinase, mouse; selenodeiodinase type 2; thyroxine deiodinase, type II, human; type 2 deiodinase (D2); type 2 selenodeiodinase; type II 5'-deiodinase
Networked: 15 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Bianco, Antonio C: 3 articles (05/2010 - 03/2004)
2. Harney, John W: 2 articles (05/2014 - 06/2005)
3. Dora, José Miguel: 2 articles (03/2014 - 06/2005)
4. Maia, Ana Luiza: 2 articles (03/2014 - 06/2005)
5. Christoffolete, Marcelo A: 2 articles (05/2010 - 03/2004)
6. Reed Larsen, P: 1 article (05/2014)
7. Singru, Praful S: 1 article (05/2014)
8. Wittmann, Gábor: 1 article (05/2014)
9. Lechan, Ronald M: 1 article (05/2014)
10. Nouriel, Shira S: 1 article (05/2014)

Related Diseases

1. Heart Diseases (Heart Disease)
2. Insulin Resistance
3. Hypothyroidism
4. Hyperthyroidism
5. Sleep Deprivation

Related Drugs and Biologics

1. Thyroxine (Levothyroxine)
2. Trans-Activators (Trans-Acting Factor)
3. Triiodothyronine (Liothyronine)
4. Tetracycline (Achromycin)
5. Genetic Markers (Genetic Marker)
6. Hormones
7. Transcription Factors (Transcription Factor)
8. Threonine (L-Threonine)
9. Propylthiouracil
10. Codon (Codons)