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proline-nitric oxide

structure in first source
Also Known As:
C5H7N3O4Na2.CH3OH; PROLI-NO
Networked: 10 relevant articles (6 outcomes, 3 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Keefer, Larry K: 8 articles (07/2015 - 10/2003)
2. Saavedra, Joseph E: 7 articles (07/2015 - 10/2003)
3. Jiang, Qun: 5 articles (06/2011 - 01/2008)
4. Kibbe, Melina R: 5 articles (06/2011 - 01/2008)
5. Martinez, Janet: 4 articles (06/2011 - 01/2008)
6. Hrabie, Joseph A: 4 articles (09/2010 - 01/2008)
7. Kapadia, Muneera R: 3 articles (12/2008 - 01/2008)
8. Vavra, Ashley K: 2 articles (06/2011 - 09/2010)
9. Weyerbrock, Astrid: 2 articles (02/2011 - 10/2003)
10. Oldfield, Edward H: 2 articles (02/2011 - 10/2003)

Related Diseases

1. Hyperplasia
2. Carotid Artery Injuries
3. Neoplasms (Cancer)
10/01/2003 - "The authors evaluated the effects of exogenous NO, which was released from a short-acting NO donor (Proli/NO), and those of NO metabolites on the capillary permeability of tumors and normal brain tissue by using quantitative autoradiography in a C6 glioma model in rats. "
02/01/2011 - "PROLI/NO selectively increased intratumoral uptake of [¹⁴C]AIB and [¹⁴C]sucrose when given as a 3-minute intracarotid infusion or a 15-minute i.v. infusion (AIB: tumor, K₁ = 68.7 ± 3.2 vs 24.9 ± 0.9 µL g⁻¹ min⁻¹, P < .0001; sucrose, K₁ = 16.9 ± 0.9 vs 11.5 ± 0.9 µL g⁻¹ min⁻¹, P = .0007). "
10/01/2003 - "The Proli/NO was infused at a wide dose range (10(-2) to 10(-12) M) either intravenously or into the internal carotid artery (ICA) and demonstrated substantial tumor-selective increases in blood-brain barrier (BBB) permeability in response to various-sized tracers ([14C]aminoisobutyric acid, [14C]sucrose, [14C]dextran). "
02/01/2011 - "As delivery and efficacy of chemotherapy is impaired in CNS neoplasms due to a partially intact blood-brain barrier (BBB), we studied the effects of NO released by the short-acting NO donor disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate methanolate (PROLI/NO) on BBB integrity and blood flow in C6 gliomas using [¹⁴C]-aminoisobutyric acid (AIB) and [¹⁴C]-iodoantipyrine quantitative autoradiography. "
02/01/2011 - "Inhibition of inducible NO synthase by aminoguanidine or cyclooxygenase inhibition by indometacin or dexamethasone did not reduce the blood-tumor barrier (BTB) response to PROLI/NO. PROLI/NO, and perhaps other NO-donating compounds, can be used to selectively increase BTB permeability in gliomas through the NO/cGMP pathway at doses that do not cause unwanted vasodilatory changes in blood flow and that do not affect the systemic circulation."
4. Glioma (Gliomas)
5. Thrombosis (Thrombus)

Related Drugs and Biologics

1. Poloxamer (Poloxamer 407)
2. Insulin (Novolin)
3. Glucose (Dextrose)
4. diazeniumdiolated poly(acrylonitrile)
5. diazeniumdiolate
6. O(2)- vinyl- 1- (pyrrolidin- 1- yl)diazen- 1- ium- 1,2- diolate
7. iodoantipyrine
8. Carboplatin (JM8)
9. Sucrose (Saccharose)
10. Nitric Oxide Synthase (NO Synthase)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Intravenous Infusions