fatty-acid amide hydrolase (fatty acid amide hydrolase)

degrades neuromodulatory fatty-acid amides including anandamide; inhibited by NSAIDS

Also Known As:

fatty acid amide hydrolase; FAAH protein, human; Fa2h protein, mouse; Faah protein, mouse; Faah protein, rat; N-arachidonoylethanolamine amidohydrolase; anandamide amidohydrolase; anandamide hydroxylase; arachidonylethanolamide hydroxylase; fatty acid amide hydrolase, human; fatty acid amide hydrolase, mouse; fatty acid amide hydrolase, rat; oleamide hydrolase

Networked: 400 relevant articles (21 outcomes, 48 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Amidohydrolases: 43
      - fatty-acid amide hydrolase: 400

Experts

1.	Cravatt, Benjamin F: 25 articles (09/2021 - 04/2004)
2.	Lichtman, Aron H: 15 articles (10/2022 - 06/2004)
3.	Piomelli, Daniele: 15 articles (07/2022 - 09/2005)
4.	Maccarrone, Mauro: 15 articles (07/2021 - 05/2003)
5.	Di Marzo, Vincenzo: 11 articles (01/2016 - 08/2002)
6.	Fowler, Christopher J: 11 articles (01/2015 - 03/2003)
7.	Hillard, Cecilia J: 10 articles (01/2018 - 12/2003)
8.	Boileau, Isabelle: 8 articles (01/2022 - 08/2015)
9.	Houle, Sylvain: 7 articles (01/2021 - 07/2013)
10.	Wilson, Alan A: 7 articles (11/2020 - 07/2013)

Related Diseases

1.	Pain (Aches) 12/01/2022 - "Inhibition of fatty acid amide hydrolase (FAAH) has shown promise in preclinical studies, ameliorating pain- and anxiety-related behaviour . " 01/01/2020 - "Modulation of Pain Sensitivity by Chronic Consumption of Highly Palatable Food Followed by Abstinence: Emerging Role of Fatty Acid Amide Hydrolase." 08/01/2019 - "We report the causative mutations for this new pain insensitivity disorder: the co-inheritance of (i) a microdeletion in dorsal root ganglia and brain-expressed pseudogene, FAAH-OUT, which we cloned from the fatty-acid amide hydrolase (FAAH) chromosomal region; and (ii) a common functional single-nucleotide polymorphism in FAAH conferring reduced expression and activity. " 10/22/2018 - "Fatty acid amide hydrolase (FAAH) can be targeted for the treatment of pain associated with various medical conditions. " 06/01/2018 - "Each of these drugs reversed all CCI-induced nociceptive measures, with the exception of the fatty acid amide hydrolase inhibitor that reversed pain-stimulated behaviors, only. "
2.	Inflammation (Inflammations) 01/01/2018 - "Fatty acid amide hydrolase (FAAH) is involved in many human diseases, particularly cancer, pain and inflammation as well as neurological, metabolic and cardiovascular disorders. " 10/13/2011 - "Here, we focus on the covalent inhibition of the fatty acid amide hydrolase (FAAH), which is a promising strategy in the treatment of pain and inflammation. " 10/01/2011 - "Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation." 03/01/2009 - "Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation." 03/01/2009 - "Recent studies suggest a role for the endocannabinoid system, including fatty acid amide hydrolase (FAAH), in intestinal inflammation. "
3.	Neuroinflammatory Diseases 11/01/2018 - "Fatty acid amide hydrolase (FAAH) represents a potential therapeutic target for number of peripheral and nervous system related disorders including neuropathic pain and neuroinflammation. " 11/15/2014 - "The present study examined the effect of enhancing fatty acid amide hydrolase (FAAH) substrate levels in vivo on Toll-like receptor (TLR)3-induced neuroinflammation. " 11/01/2022 - "Fatty acid amide hydrolase (FAAH), aserinehydrolase with significant role in thehydrolysis of endocannabinoids, is a promising therapeutic target for peripheral and central nervous system related disorders, including pain, neuroinflammation and depression. " 12/01/2017 - "The present study explored the protective effects of cannabinoid receptor agonist WIN55,212-2 (WIN) and fatty acid amide hydrolase inhibitor URB597 (URB) against neuroinflammation in rats with chronic cerebral hypoperfusion (CCH). " 01/15/2023 - "The neuroprotective performance against neuroinflammation of the endocannabinoid system (ECS) can be remarkably improved by indirect stimulation mediated by the pharmacological inhibition of the key ECS catabolic enzyme fatty acid amide hydrolase (FAAH). "
4.	Colitis 01/01/2021 - "Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase." 01/01/2021 - "Genetic Variants of Fatty Acid Amide Hydrolase Modulate Acute Inflammatory Responses to Colitis in Adult Male Mice." 09/01/2014 - "Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH)." 01/01/2017 - "Fatty acid amide hydrolase (FAAH) blockade ameliorates experimental colitis by altering microRNA expression and suppressing inflammation." 09/01/2014 - "Here we aimed to assess the anti-inflammatory action of the novel fatty acid amide hydrolase (FAAH) inhibitor PF-3845 and its effect on the endocannabinoid and related lipid metabolism during the course of experimental colitis. "
5.	Lung Injury 08/01/2017 - "The Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates Radiation-Induced Lung Injury in a Mouse Model." 01/01/2019 - "Posttreatment With the Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates One-Lung Ventilation-Induced Lung Injury in a Rabbit Model."

Related Drugs and Biologics

1.	Enzymes
2.	anandamide (arachidonylethanolamide)
3.	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester (URB597)
4.	Endocannabinoids
5.	Cannabinoid Receptor Agonists
6.	Monoacylglycerol Lipases
7.	URB937
8.	Ligands
9.	Glycerol (Glycerine)
10.	MicroRNAs (MicroRNA)

Related Therapies and Procedures

1.	One-Lung Ventilation
2.	Therapeutics
3.	Analgesia
4.	Gluten-Free Diet
5.	Biliopancreatic Diversion