thrombospondin 2

a member of the family of thrombospondin glycoproteins; naturally occurring inhibitor of angiogenesis; TSP1 AND TSP2 have similar structures, but are expressed during different times in development

Also Known As:

THBS2 protein, human; TSP-2 protein, human; TSP-2 protein, mouse; TSP-2 protein, rat; TSP2 protein, human; TSP2 protein, mouse; TSP2 protein, rat; Thbs2 protein, mouse; Thbs2 protein, rat; thrombospondin 2 protein, human; thrombospondin 2 protein, mouse; thrombospondin 2 protein, rat; thrombospondin-2 protein, mouse

Networked: 74 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yamada, Yoshiji: 3 articles (05/2015 - 04/2007)
2.	Chen, Po-Chun: 2 articles (01/2021 - 01/2018)
3.	Liu, Ju-Fang: 2 articles (01/2021 - 01/2018)
4.	Tang, Chih-Hsin: 2 articles (01/2021 - 01/2018)
5.	Daniel, Christoph: 2 articles (01/2013 - 03/2007)
6.	Hugo, Christian: 2 articles (01/2013 - 03/2007)
7.	Kato, Kimihiko: 2 articles (03/2009 - 04/2007)
8.	Metoki, Norifumi: 2 articles (03/2009 - 04/2007)
9.	Nozawa, Yoshinori: 2 articles (03/2009 - 04/2007)
10.	Satoh, Kei: 2 articles (03/2009 - 04/2007)

Related Diseases

1.	Intervertebral Disc Degeneration 01/01/2018 - "The aim of this study is to determine the contribution of 2 single nucleotide polymorphisms (SNPs) in thrombospondin 2 (THBS2) gene to the development of intervertebral disc degeneration (IDD) in a Chinese Han population.We" 01/01/2014 - "We also report two novel disc degeneration-related SNPs (rs2095019 and rs470859) located in intergenic regions upstream to thrombospondin 2. Findings contribute to the challenging field of disc degeneration and pain, and are important in light of the high clinical relevance of low back pain and the need for improved understanding of its fundamental basis."
2.	Hypertension (High Blood Pressure) 03/01/2009 - "Subsequent multivariable logistic regression analysis with adjustment for age, gender and the prevalence of diabetes mellitus revealed that these two polymorphisms, 3949T↷G (3'-UTR) of the thrombospondin 2 gene (THBS2; odds ratio in recessive model, 8.31) and -110A↷C of the heat shock 70-kDa protein 8 gene (HSPA8; odds ratio in recessive model, 0.72) were significantly (P<0.05) associated with the prevalence of hypertension. " 05/01/2015 - "Longitudinal analysis with a generalized estimating equation, and with adjustment for age, gender, body mass index, smoking status, the prevalence of hypertension, diabetes mellitus and dyslipidemia and the serum concentration of creatinine, revealed that rs2074380 (G→A) and rs2074381 (A→G) of the α-kinase 1 (ALPK1) gene and rs8089 (T→G) of the thrombospondin 2 (THBS2) gene were significantly (P<2×10-16) associated with the prevalence of CAD, with the AA genotype of rs2074380 and GG genotypes of rs2074381 and rs8089 being protective against this condition. "
3.	Diabetes Mellitus 03/01/2009 - "Subsequent multivariable logistic regression analysis with adjustment for age, gender and the prevalence of diabetes mellitus revealed that these two polymorphisms, 3949T↷G (3'-UTR) of the thrombospondin 2 gene (THBS2; odds ratio in recessive model, 8.31) and -110A↷C of the heat shock 70-kDa protein 8 gene (HSPA8; odds ratio in recessive model, 0.72) were significantly (P<0.05) associated with the prevalence of hypertension. " 05/01/2015 - "Longitudinal analysis with a generalized estimating equation, and with adjustment for age, gender, body mass index, smoking status, the prevalence of hypertension, diabetes mellitus and dyslipidemia and the serum concentration of creatinine, revealed that rs2074380 (G→A) and rs2074381 (A→G) of the α-kinase 1 (ALPK1) gene and rs8089 (T→G) of the thrombospondin 2 (THBS2) gene were significantly (P<2×10-16) associated with the prevalence of CAD, with the AA genotype of rs2074380 and GG genotypes of rs2074381 and rs8089 being protective against this condition. "
4.	Dyslipidemias (Dyslipidemia) 05/01/2015 - "Longitudinal analysis with a generalized estimating equation, and with adjustment for age, gender, body mass index, smoking status, the prevalence of hypertension, diabetes mellitus and dyslipidemia and the serum concentration of creatinine, revealed that rs2074380 (G→A) and rs2074381 (A→G) of the α-kinase 1 (ALPK1) gene and rs8089 (T→G) of the thrombospondin 2 (THBS2) gene were significantly (P<2×10-16) associated with the prevalence of CAD, with the AA genotype of rs2074380 and GG genotypes of rs2074381 and rs8089 being protective against this condition. "
5.	Low Back Pain (Lumbago) 01/01/2014 - "We also report two novel disc degeneration-related SNPs (rs2095019 and rs470859) located in intergenic regions upstream to thrombospondin 2. Findings contribute to the challenging field of disc degeneration and pain, and are important in light of the high clinical relevance of low back pain and the need for improved understanding of its fundamental basis."

Related Drugs and Biologics

1.	Intergenic DNA (Junk DNA)
2.	Phosphotransferases (Kinase)
3.	Creatinine
4.	Ligands
5.	Proteins (Proteins, Gene)
6.	Osteopontin
7.	Thrombospondin 1
8.	Chemokines
9.	Cadherins (E-Cadherin)
10.	RANK Ligand

Related Therapies and Procedures

1.	Neoadjuvant Therapy