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T 440

a selective type IV phosphodiesterase inhibitor; structure given in first source

Also Known As:

4-(6,7-diethoxy-2,3-bis(hydroxymethyl)-1-naphthyl)-1-(2-methoxyethyl)-2(1H)-pyridone; T-440

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        T 440: 2
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - T 440: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Pyridones: 14
      - T 440: 2

Related Diseases

1.

Inflammation (Inflammations)

01/01/1996 - "T-440 may be an effective agent to treat atopic diseases associated with eosinophilic inflammation, e.g. "
10/01/1996 - "We conclude that T-440 suppressed cytokine production by peripheral T lymphocytes via the protein kinase A pathway and may be an effective modality to treat atopic diseases associated with eosinophilic inflammation."
01/01/1996 - "A novel phosphodiesterase inhibitor, T-440: possible management of eosinophilic inflammation by down-regulation of interleukin-5 production."

Related Drugs and Biologics

1.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
2.	Cytokines
3.	Interleukin-5 (Interleukin 5)
4.	Phosphodiesterase Inhibitors