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MDL 105519

a potent ligand at the N-methyl-D-aspartate (NMDA) receptor-associated glycine recognition site; structure given in first source

Also Known As:

3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1H-indole-2-carboxylic acid; MDL 105,519; MDL-105519

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - MDL 105519: 1

Experts

1.	Kakuda, Takami: 1 article (12/2002)
2.	Niino, Hitoshi: 1 article (12/2002)
3.	Nozawa, Ayumu: 1 article (12/2002)
4.	Sugimoto, Akio: 1 article (12/2002)

Related Diseases

1.

Brain Ischemia (Cerebral Ischemia)

12/01/2002 - "In an investigation of the mechanisms of the neuroprotective effects of theanine (gamma-glutamylethylamide) in brain ischemia, inhibition by theanine of the binding of [3H](RS)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, and [3H](E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1-H-indole-2-carboxylic acid (MDL 105,519) to glutamate receptors was studied in terms of its possible inhibiting effects on the three receptor subtypes (AMPA, kainate, and NMDA glycine), with rat cortical neurons. "

Related Drugs and Biologics

1.	Neuroprotective Agents
2.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
3.	Glutamate Receptors (Glutamate Receptor)
4.	N-Methylaspartate (NMDA)
5.	Kainic Acid (Kainate)
6.	Glycine (Aminoacetic Acid)
7.	Carboxylic Acids
8.	indole
9.	propionic acid (potassium propionate)
10.	theanine