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2- (2- (4- (4- nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate

inhibits the reverse mode of Na+/Ca++ exchange in cells expressing NCX1; structure in first source
Also Known As:
KB R7943; KB-7943; KB-R7943; KBR 7943; KBR-7943; KBR7943; No 7943; compound No. 7943
Networked: 64 relevant articles (13 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Jia, Dalin: 4 articles (11/2014 - 07/2011)
2. Ren, Yongkui: 3 articles (11/2014 - 11/2012)
3. Mattiazzi, Alicia: 3 articles (06/2010 - 01/2002)
4. Said, Matilde: 3 articles (06/2010 - 01/2002)
5. Iwamoto, Takahiro: 3 articles (03/2007 - 01/2003)
6. Kita, Satomi: 3 articles (03/2007 - 01/2003)
7. Cai, Yunfei: 2 articles (11/2014 - 11/2012)
8. Lv, Yan: 2 articles (11/2014 - 06/2013)
9. Sun, Yanjuan: 2 articles (06/2014 - 10/2009)
10. Hong, Haifa: 2 articles (06/2014 - 10/2009)

Related Diseases

1. Acute Kidney Injury (Acute Renal Failure)
2. Ischemia
02/01/1998 - "In the hearts subjected to 25-min ischemia and 30-min reperfusion, KB-R7943 concentration-dependently and significantly improved post-ischemic recovery of left ventricular developed pressure, left ventricular dP/dtmax and left ventricular end-diastolic pressure by pre-ischemic treatment (5 min) or post-ischemic treatment (10 min). "
09/01/2001 - "The observed electrophysiological profile of KB-R7943 and its protective effects on ischemia-reperfusion-induced ventricular arrhythmias support the notion of a prominent role of Ca2+ entry via reverse Na+/Ca2+ exchange in this process."
10/19/2001 - "In this study, we evaluated the effects of KB-R7943 (50 microM), a specific inhibitor of the reverse mode of NCX, applied topically onto rat cerebral cortex prior to and during ischemia. "
05/01/2010 - "Each series had its own control ischemia group, the other groups were postconditioning with three cycles of 10 s of reperfusion and 10 s of ischemia immediately after sustained ischemia; the vehicle of the NCX blocker KB-R7943 was added to the perfusate 5 min before ischemia in series 1; KB-R7943 was added to the perfusate 5 min before ischemia with and without postconditioning in series 2; KB-R7943 was added to the perfusate for 5 min from the start of reperfusion with and without postconditioning in series 3. Infarct size was measured and cardiac function was evaluated. "
02/02/2008 - "However, higher concentrations of KB-R7943 (0.5 and 1.0 microM) reduced the magnitude of Ca(2+) current and promoted action potential abbreviation in both ischemia and reperfusion. "
3. Anoxia (Hypoxia)
4. Tachycardia (Tachyarrhythmias)
5. Infarction

Related Drugs and Biologics

1. 2- (2- (4- (4- nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate
2. cariporide
3. methanesulfonic acid (methanesulfonate)
4. Tacrolimus (Prograf)
5. Bepridil (Vascor)
6. Mesylates (Mesylate)
7. hydroxide ion
8. Adenosine Triphosphate (ATP)
9. Nicorandil (SG 75)
10. mitochondrial K(ATP) channel

Related Therapies and Procedures

1. Ischemic Postconditioning
2. Intravenous Injections