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LY 306089

testosterone 5-alpha-reductase antagonist; structure given in first source

Also Known As:

8,9-dichloro-4,10b-dimethyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinolin-3-one; LY306089

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Quinones: 434
  - Benzoquinones: 25
    - LY 306089: 1

Related Diseases

1.

Castration-Resistant Prostatic Neoplasms

05/01/1996 - "LY306089 was a non-competitive inhibitor of type I 5 alpha-reductase in DU145 cellular homogenates with an apparent Ki value of 4.0 nM. These studies have identified and pharmacologically defined type I 5 alpha-reductase activity in an androgen-insensitive prostatic cancer cell line and provide the basis for additional investigations into the significance of type I 5 alpha-reductase to human prostatic pathophysiology."

Related Drugs and Biologics

1.	Cholestenone 5 alpha-Reductase (5 alpha-Reductase)