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8-hydroxywarfarin

metabolic marker for (S)-mephenytoin hydroxylase (P4502C19); structure in first source

Also Known As:

8-hydroxywarfarin, (+-)-isomer; 8-hydroxywarfarin, (R)-isomer; 8-hydroxywarfarin, (S)-isomer

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        4-Hydroxycoumarins: 2
        Warfarin: 13728
        8-hydroxywarfarin: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        4-Hydroxycoumarins: 2
        Warfarin: 13728
        8-hydroxywarfarin: 1

Related Diseases

1.

Cystic Fibrosis (Mucoviscidosis)

05/01/1994 - "The unbound metabolic clearances of (R)-warfarin to its oxidative metabolites--6-hydroxywarfarin, 7-hydroxywarfarin, 8-hydroxywarfarin, and 10-hydroxywarfarin (mediated by P450 3A4)--were also similar (p > 0.05) in the two groups (6-hydroxywarfarin: cystic fibrosis: 124.2 +/- 72.8 ml/hr/kg, control: 99.4 +/- 37.3 ml/hr/kg; 7-hydroxywarfarin: cystic fibrosis: 43.8 +/- 32.2 ml/hr/kg, control: 34.5 +/- 10.6 ml/hr/kg; 8-hydroxywarfarin: cystic fibrosis: 80.4 +/- 85.4 ml/hr/kg, control: 69.5 +/- 39.5 ml/hr/kg; 10-hydroxywarfarin: cystic fibrosis: 4.38 +/- 2.72 ml/hr/kg, control: 16.28 +/- 13.71 ml/hr/kg). "

Related Drugs and Biologics

1.	Warfarin (Coumadin)
2.	7-hydroxywarfarin
3.	10-hydroxywarfarin