HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

panepoxydone

structure given in first source; RN refers to (1S-(1alpha,3(S*),5alpha,6alpha))-isomer

Also Known As:

5-hydroxy-3-(1-hydroxy-3-methyl-2-butenyl)-7-oxabicylo(4.1.0)hept-3-en-2-one

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - panepoxydone: 4

Experts

1.	Arora, Ritu: 2 articles (01/2015 - 01/2014)
2.	Dean-Colomb, Windy: 2 articles (01/2015 - 01/2014)
3.	Tan, Ming: 2 articles (01/2015 - 01/2014)
4.	Yates, Clayton: 2 articles (01/2015 - 01/2014)
5.	Karanam, Balasubramanyam: 1 article (01/2015)
6.	Schmitt, David: 1 article (01/2015)
7.	Gary, Bernard D: 1 article (01/2014)
8.	McClellan, Steven: 1 article (01/2014)
9.	Owen, Laurie B: 1 article (01/2014)
10.	Piazza, Gary A: 1 article (01/2014)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2014 - "Here we report for the first time the anti-tumor activity of panepoxydone (PP), a NF-κB inhibitor isolated from an edible mushroom, in several breast cancer cell lines. " 01/01/2014 - "Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer." 02/02/2023 - "For instance, panepoxydone exerted protective mechanisms against breast cancer initiation and progression by suppressing lactate dehydrogenase A expression levels and reinducing lactate dehydrogenase B expression levels. " 01/20/2015 - "Panepoxydone (PP), a natural NF-kB inhibitor, significantly reduces the oxygen consumption and lactate production of MCF-7 and triple negative (MDA-MB-231, MDA-MB-468 and MDA-MB-453) breast cancer cells. "
2.	Neoplasms (Cancer) 01/01/2014 - "Here we report for the first time the anti-tumor activity of panepoxydone (PP), a NF-κB inhibitor isolated from an edible mushroom, in several breast cancer cell lines. "
3.	Inflammation (Inflammations) 05/01/2007 - "DNA microarray analysis of 110 human genes known to be strongly regulated during inflammation, combined with reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) revealed that low micromolar concentrations (12-24 microM) of panepoxydone strongly inhibited the expression of thirty-three NF-kappaB dependent pro-inflammatory genes such as the chemokines CCL3, CCL4, CCL8; CXCL8, CXCL10, CXCL20, the cytokines IL-1, IL-6, TNF-alpha, pro-inflammatory enzymes like COX-2, and components of the REL/NF-kappaB/IkappaB family without significant effects on the expression of house-keeping genes. "

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)
2.	Lactic Acid (Lactate)
3.	Chemokines
4.	Cytokines
5.	Interleukin-6 (Interleukin 6)
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Interleukin-1 (Interleukin 1)
8.	Enzymes
9.	DNA (Deoxyribonucleic Acid)
10.	Lactate Dehydrogenase 5