altinicline maleate

binds to neuronal nicotinic acetylcholine receptors

Also Known As:

5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate; SIB 1508Y; SIB-1508Y; (-)-3-ethynyl-5-((S)-1-methyl-2-pyrrolidinyl)pyridine maleate (1:1)

Networked: 5 relevant articles (2 outcomes, 2 trials/studies)

1.	Adams, Pamala B: 1 article (10/2008)
2.	Correa, Lucia D: 1 article (10/2008)
3.	Cosford, Nicholas D P: 1 article (10/2008)
4.	Rao, Tadimeti S: 1 article (10/2008)
5.	Reid, Richard T: 1 article (10/2008)
6.	Sacaan, Aida I: 1 article (10/2008)
7.	Santori, Emily M: 1 article (10/2008)
8.	Parkinson Study Group: 1 article (02/2006)

1.	Parkinson Disease (Parkinson's Disease) 08/01/1999 - "Thus, SIB-1508Y may be useful in the treatment of the cognitive deficits in Parkinson's disease." 10/09/2008 - "In rodents, SIB-1508Y exhibited antidepressant activity, reversed age-related decrements in vigilance, and improved motor and cognitive function in primate models of Parkinson's disease. " 02/14/2006 - "This randomized, placebo-controlled, 5-week Phase II trial evaluated the safety and tolerability of SIB-1508Y, a selective alpha4beta2 nicotinic acetylcholine receptor agonist, in 77 individuals with early Parkinson disease. " 02/14/2006 - "Randomized placebo-controlled study of the nicotinic agonist SIB-1508Y in Parkinson disease." 03/01/1998 - "These results suggest the potential usefulness of SIB-1508Y and levodopa as adjunctive therapies to improve at least some of the cognitive and motor deficits associated with Parkinson's disease."
2.	Alzheimer Disease (Alzheimer's Disease) 01/01/1998 - "Preclinical studies suggest that SIB-1508Y is a candidate for the treatment of the motor and cognitive deficits of Parkinson's disease, whereas SIB-1553A appears to have potential as a candidate for the treatment of Alzheimer's disease. "

1.	Antidepressive Agents (Antidepressants)
2.	Nicotinic Agonists
3.	nicotinic receptor alpha4beta2
4.	4- ((2- (1- methyl- 2- pyrrolidinyl)ethyl)thio)phenol hydrochloride
5.	Levodopa (L Dopa)

1.	Therapeutics