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MI 1892
Also Known As:
Ac-1,3-Trp-2-Cpa-5-Lys-6-(beta-Asp(DEA))-8-Gln-10-Ala-GnRH; GnRH, Ac-Trp(1,3)-Cpa(2)-Lys(5)-(beta-Asp(DEA))(6)-Gln(8)-Ala(10)-; GnRH, acetyl-tryptophyl(1,3)-4-chlorophenylalanyl(2)-lysyl(5)-(beta-aspartyl(DEA))(6)-glutaminyl(8)-alanyl(10)-; MI-1892
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Peptide Hormones: 1347
Hypothalamic Hormones: 68
Pituitary Hormone-Releasing Hormones: 39
Gonadotropin-Releasing Hormone: 10670
MI 1892: 2
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Nerve Tissue Proteins: 2
Neuropeptides: 6772
Hypothalamic Hormones: 68
Pituitary Hormone-Releasing Hormones: 39
Gonadotropin-Releasing Hormone: 10670
MI 1892: 2
Peptides: 82426
Neuropeptides: 6772
Hypothalamic Hormones: 68
Pituitary Hormone-Releasing Hormones: 39
Gonadotropin-Releasing Hormone: 10670
MI 1892: 2
Peptide Hormones: 1347
Hypothalamic Hormones: 68
Pituitary Hormone-Releasing Hormones: 39
Gonadotropin-Releasing Hormone: 10670
MI 1892: 2
Oligopeptides: 519
Gonadotropin-Releasing Hormone: 10670
MI 1892: 2
Related Diseases
1.
Neoplasms (Cancer)
01/01/1996 - "
The in vivo experiments with the human GnRH antagonist MI-1544 (Ac-D-Trp1,3,D-Cpa2,D-Lys6,D-Ala10)-GnRH, the chicken GnRH antagonist MI-1892 (Ac-D-Trp1,3,D-Cpa2,Lys5,/beta-Asp(DEA)/6,Gln8,D-Al a10)-GnRH, and their copolymer conjugates were carried out on MCF-7 and MDA-MB-231 human breast tumors xenografted in immunosuppressed CBA/Ca HRIJ-T6 female mice and on MXT mouse mammary tumors in BDF1 mice.
"
03/02/1999 - "
Conjugation of gonadotropin-releasing hormone (GnRH) analogues GnRH-III, MI-1544, and MI-1892 through lysyl side chains and a tetrapeptide spacer, Gly-Phe-Leu-Gly (X) to a copolymer, poly(N-vinylpyrrolidone-co-maleic acid) (P) caused increased antiproliferative activity toward MCF-7 and MDA-MB-231 breast, PC3 and LNCaP prostate, and Ishikawa endometrial cancer cell lines in culture and against tumor development by xenografts of the breast cancer cells in immunodeficient mice.
"
2.
Breast Neoplasms (Breast Cancer)
01/01/1996 - "
The in vivo experiments with the human GnRH antagonist MI-1544 (Ac-D-Trp1,3,D-Cpa2,D-Lys6,D-Ala10)-GnRH, the chicken GnRH antagonist MI-1892 (Ac-D-Trp1,3,D-Cpa2,Lys5,/beta-Asp(DEA)/6,Gln8,D-Al a10)-GnRH, and their copolymer conjugates were carried out on MCF-7 and MDA-MB-231 human breast tumors xenografted in immunosuppressed CBA/Ca HRIJ-T6 female mice and on MXT mouse mammary tumors in BDF1 mice.
"
03/02/1999 - "
Conjugation of gonadotropin-releasing hormone (GnRH) analogues GnRH-III, MI-1544, and MI-1892 through lysyl side chains and a tetrapeptide spacer, Gly-Phe-Leu-Gly (X) to a copolymer, poly(N-vinylpyrrolidone-co-maleic acid) (P) caused increased antiproliferative activity toward MCF-7 and MDA-MB-231 breast, PC3 and LNCaP prostate, and Ishikawa endometrial cancer cell lines in culture and against tumor development by xenografts of the breast cancer cells in immunodeficient mice.
"
3.
Endometrial Neoplasms (Endometrial Cancer)
03/02/1999 - "
Conjugation of gonadotropin-releasing hormone (GnRH) analogues GnRH-III, MI-1544, and MI-1892 through lysyl side chains and a tetrapeptide spacer, Gly-Phe-Leu-Gly (X) to a copolymer, poly(N-vinylpyrrolidone-co-maleic acid) (P) caused increased antiproliferative activity toward MCF-7 and MDA-MB-231 breast, PC3 and LNCaP prostate, and Ishikawa endometrial cancer cell lines in culture and against tumor development by xenografts of the breast cancer cells in immunodeficient mice.
"
Related Drugs and Biologics
1.
Gonadotropin-Releasing Hormone (GnRH)
2.
MI 1544
3.
Gly-Phe-Leu-Gly
4.
gonadotropin-releasing hormone-III
5.
antineoplaston A10 (A 10)
6.
N-vinyl-2-pyrrolidinone
7.
maleic acid (maleate)