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demethoxyfumitremorgin C

isolated from the fermentation broth of Aspergillus fumigatus; a mammalian cell cycle inhibitor; structure given in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - demethoxyfumitremorgin C: 1

Experts

1.	Kim, Se-Kwon: 1 article (05/2017)
2.	Kim, Young-Sang: 1 article (05/2017)
3.	Park, Sun Joo: 1 article (05/2017)

Related Diseases

1.

Prostatic Neoplasms (Prostate Cancer)

05/01/2017 - "Demethoxyfumitremorgin C could therefore, serve as a useful agent to treat human advanced prostate cancer."
05/01/2017 - "These results suggest that demethoxyfumitremorgin C from Aspergillus fumigatus inhibits the proliferation of PC3 human prostate cancer cells via the intrinsic (mitochondrial) and extrinsic pathway, followed by downstream events leading to apoptotic cell death. "
05/01/2017 - "Apoptotic effect of demethoxyfumitremorgin C from marine fungus Aspergillus fumigatus on PC3 human prostate cancer cells."
05/01/2017 - "We found that treatment of demethoxyfumitremorgin C inhibited the cell viability of PC3 human advanced prostate cancer cells, induced apoptosis as determined by Annexin V/propidium iodide double staining, and decreased mitochondrial membrane potential. "

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