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factor H-related protein 1

from plasma; N-terminal amino acid sequence given in first source

Also Known As:

FHR-1alpha; FHR-1beta; FHRP-1; factor H-related protein p43

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - factor H-related protein 1: 8

Experts

1.	Sánchez-Corral, Pilar: 3 articles (01/2022 - 08/2011)
2.	Józsi, Mihály: 3 articles (04/2015 - 08/2011)
3.	Rodríguez de Córdoba, Santiago: 2 articles (01/2022 - 08/2012)
4.	Tortajada, Agustín: 2 articles (01/2022 - 08/2012)
5.	Prohászka, Zoltán: 2 articles (04/2015 - 08/2012)
6.	Seeberger, Harald: 2 articles (04/2015 - 08/2011)
7.	Strobel, Stefanie: 2 articles (08/2012 - 08/2011)
8.	Caravaca-Fontán, Fernando: 1 article (01/2022)
9.	Elías, Sandra: 1 article (01/2022)
10.	Fernández-Juarez, Gema: 1 article (01/2022)

Related Diseases

1.	Inflammation (Inflammations) 11/18/2021 - "The present study found that homozygous deletion of the CFHR1 gene, which encodes the plasma complement protein factor H-related protein 1 (FHR-1), was protective in two cohorts of patients with ACVD, suggesting that FHR-1 accelerates inflammation and exacerbates the disease. "
2.	Atypical Hemolytic Uremic Syndrome 01/01/2020 - "Deficiency of factor H-related protein 1 (FHR-1), which is a regulator of AP, has been considered as a susceptible factor for atypical hemolytic uremic syndrome (aHUS) and other types of nephropathy when an inducer such as infection exists. " 04/10/2015 - "The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model for induction of autoimmunity in this disease." 08/15/2012 - "Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3."
3.	Disease Progression 10/01/2017 - "These results also suggest that factor H-related protein 1 levels may be useful for identifying those patients at high risk of disease progression." 10/01/2017 - "In this issue, 2 groups report that levels of factor H-related protein 1 are elevated in patients with IgA nephropathy and correlate with disease progression. "
4.	Infections 01/01/2020 - "Deficiency of factor H-related protein 1 (FHR-1), which is a regulator of AP, has been considered as a susceptible factor for atypical hemolytic uremic syndrome (aHUS) and other types of nephropathy when an inducer such as infection exists. "
5.	Hemolytic-Uremic Syndrome 08/01/2011 - "Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome."

Related Drugs and Biologics

1.	Complement System Proteins (Complement)
2.	Complement Factor H (Factor H)
3.	Autoantibodies
4.	Pregnancy-Associated alpha 2-Macroglobulins (alpha 2 Macroglobulin)
5.	Immunoglobulins (Immunoglobulin)
6.	Haptoglobins
7.	Epitopes
8.	PTX3 protein