chicoric acid

inhibits HIV-1 integrase

Also Known As:

(-)-L-chicoric acid; (-)-chicoric acid; (2R,3R)-2,3-bis(((2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl)oxy)-butanedioic acid; L-chicoric acid; cichoric acid; dicaffeoyltartaric acid

Networked: 56 relevant articles (12 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - Succinates: 13
        chicoric acid: 56
  - Carbocyclic Acids
    - Cinnamates: 48
      - Caffeic Acids: 15
        chicoric acid: 56

Experts

1.	Liu, Xuebo: 4 articles (09/2019 - 12/2015)
2.	Liu, Zhigang: 4 articles (09/2019 - 12/2015)
3.	Liu, Qian: 3 articles (04/2020 - 01/2017)
4.	Wang, Yutang: 3 articles (09/2018 - 12/2015)
5.	Chen, Jian: 2 articles (03/2022 - 01/2020)
6.	Li, Jing: 2 articles (03/2022 - 01/2020)
7.	Qian, He: 2 articles (02/2022 - 02/2022)
8.	Wang, Ning: 2 articles (02/2022 - 02/2022)
9.	Abbasalipourkabir, Roghayeh: 2 articles (07/2020 - 01/2019)
10.	Ziamajidi, Nasrin: 2 articles (07/2020 - 01/2019)

Related Diseases

1.	Inflammation (Inflammations) 09/01/2019 - "Chicoric acid improves neuron survival against inflammation by promoting mitochondrial function and energy metabolism." 02/01/2018 - "In addition, ROS production and inflammation were significantly suppressed following treatment with chicoric acid. " 01/01/2017 - "Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB." 12/24/2015 - "Effect of Chicoric Acid on Mast Cell-Mediated Allergic Inflammation in Vitro and in Vivo." 08/01/2022 - "Protective effects of chicoric acid on polyinosinic-polycytidylic acid exposed chicken hepatic cell culture mimicking viral damage and inflammation."
2.	Non-alcoholic Fatty Liver Disease 01/01/2017 - "CDE and chicoric acid may be effective in the treatment of NAFLD and NASH." 01/01/2020 - "Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NFκB Signaling Pathway and Restores Gut Microbiota in High-Fat-Diet-Fed Mice." 01/01/2020 - "This study examines the effects of chicoric acid (CA) on nonalcoholic fatty liver disease (NAFLD) in high-fat-diet- (HFD-) fed C57BL/6 mice. " 01/01/2017 - "Chicoric acid has beneficial effects on obesity and liver injury, but its effects on nonalcoholic steatohepatitis (NASH) have not yet been determined. " 02/01/2023 - "The main aim of this study is to evaluate the synergistic treatment effect of fish oils (FOs) and chicoric acid (CA) in palmitate (PA)-induced NAFLD HepG2 model. "
3.	Ototoxicity 06/16/2022 - "The present study aimed to investigate the protective effects of cichoric acid against neomycin-induced ototoxicity using transgenic zebrafish (pvalb3b: TagGFP). "
4.	Neoplasms (Cancer) 03/10/2020 - "This work provides a powerful new platform for the highly accurate measurement of chicoric acid quantities, facilitating further research into its potential as a cancer treatment." 03/10/2020 - "Chicoric acid, a phenolic compound widely distributed in many plants, has drawn widespread attention in recent years because of its extraordinary anti-cancer activities. " 09/19/2022 - "Further, a commercially available hit compound, Chicoric acid, was evaluated for its anti-cancer potential against PHGDH-expressing gastric cancer cell lines (MGC-803 and SGC-7901) as well as cell lines with low expression of PHGDH (MCF-7 and MDA-MB2-31), which demonstrated that Chicoric acid possesses selective cytotoxicity toward PHGDH expressing cancer cell lines. " 03/10/2020 - "An Ultrasensitive Non-Enzymatic Sensor for Quantitation of Anti-Cancer Substance Chicoric Acid Based on Bimetallic Nanoalloy with Polyetherimide-Capped Reduced Graphene Oxide." 01/01/2015 - "OB extracts not only improve taste but also have certain anticancer activity against diverse cancer cells due to the presence of compounds such as rosmarinic acid, chicoric acid and caftaric acid. "
5.	Stomach Neoplasms (Stomach Cancer) 10/01/2019 - "Chicoric acid (CA) induces autophagy in gastric cancer through promoting endoplasmic reticulum (ER) stress regulated by AMPK." 09/19/2022 - "Further, a commercially available hit compound, Chicoric acid, was evaluated for its anti-cancer potential against PHGDH-expressing gastric cancer cell lines (MGC-803 and SGC-7901) as well as cell lines with low expression of PHGDH (MCF-7 and MDA-MB2-31), which demonstrated that Chicoric acid possesses selective cytotoxicity toward PHGDH expressing cancer cell lines. "

Related Drugs and Biologics

1.	Palmitates
2.	Poly I-C
3.	Neomycin
4.	Polysaccharides (Glycans)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	sphingosine 1-phosphate (sphingosine-1-phosphate)
7.	Hypoglycemic Agents (Hypoglycemics)
8.	Galactosamine
9.	Ethanol (Ethyl Alcohol)
10.	Tretinoin (Retinoic Acid)

Related Therapies and Procedures

1.	Therapeutics