3,5-dicaffeoylquinic acid

inhibits HIV-1 integrase

Also Known As:

(3R,5R)-3,5-bis(((2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl))-1,4-dihydroxy-cyclohexanecarboxylic acid; 3,5-DCQA; 3,5-H56:H75dicaffeoyl-epi-quinic acid; 3,5-O-dicaffeoylquinic acid; 3,5-di-O-caffeoylquinic acid; CJ 4-16-4; CJ-4-16-4; isochlorogenic acid A

Networked: 32 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Cinnamates: 48
      - Chlorogenic Acid: 681
        3,5-dicaffeoylquinic acid: 32
    - Cyclohexanecarboxylic Acids
      - Chlorogenic Acid: 681
        3,5-dicaffeoylquinic acid: 32

Experts

1.	Liu, Guangli: 2 articles (02/2021 - 01/2021)
2.	Wang, Zhang: 2 articles (02/2021 - 01/2021)
3.	Jung, Sang Hoon: 2 articles (02/2014 - 09/2011)
4.	Kim, Kyung-A: 2 articles (02/2014 - 09/2011)
5.	Nho, Chu Won: 2 articles (02/2014 - 09/2011)
6.	Han, Junkyu: 2 articles (10/2012 - 01/2011)
7.	Isoda, Hiroko: 2 articles (10/2012 - 01/2011)
8.	Kurisu, Manami: 2 articles (10/2012 - 01/2011)
9.	Miyamae, Yusaku: 2 articles (10/2012 - 01/2011)
10.	Shigemori, Hideyuki: 2 articles (10/2012 - 01/2011)

Related Diseases

1.	Pain (Aches) 09/01/2022 - "This study aimed to investigate the effects of 3,5-DCQA on microglial activation-induced inflammatory pain. " 09/01/2022 - "Therefore, 3,5-DCQA could be a potential therapeutic agent for alleviating inflammatory pain." 09/01/2022 - "3,5-Dicaffeoylquinic acid attenuates microglial activation-mediated inflammatory pain by enhancing autophagy through the suppression of MCP3/JAK2/STAT3 signaling." 09/01/2022 - "The CFA-induced pain hypersensitivity and foot swelling were attenuated by the oral administration of 3,5-DCQA. " 09/01/2022 - "Our findings indicate that 3,5-DCQA attenuates inflammation-mediated pain hypersensitivity by enhancing autophagy through inhibition of MCP3-induced JAK2/STAT3 signaling. "
2.	Inflammation (Inflammations) 01/01/2019 - "Levels of lung active markers and inflammation factors induced by LPS were reversed by isochlorogenic acid A. " 09/01/2022 - "Our findings indicate that 3,5-DCQA attenuates inflammation-mediated pain hypersensitivity by enhancing autophagy through inhibition of MCP3-induced JAK2/STAT3 signaling. " 01/01/2019 - "The effects of oxidant stress, pulmonary edema and inflammation factors induced by LPS were inhibited by isochlorogenic acid A. " 09/01/2022 - "3,5-dicaffeoylquinic acid (3,5-DCQA) has shown protective effects against inflammation-related diseases, but the effect of 3,5-DCQA on microglial activation and inflammatory pain is not evaluated. " 01/01/2023 - "The major components in QKL Oral Prescription, including hyodeoxycholic acid, baicalin, chlorogenic acid, isochlorogenic acid C, epigoitrin, geniposide, cholic acid, isochlorogenic acid A, and γ-aminobutyric acid, may interfere with multiple biological processes related to inflammation, immune regulation, fever, and convulsion by acting on the key protein targets such as IL-6, TNF, prostaglandin-endoperoxide synthase 2(PTGS2), arachidonate 5-lipoxygenase(ALOX5), vascular cell adhesion molecule 1(VCAM1), nitric oxide synthase 2(NOS2), prostaglandin E2 receptor EP2 subtype(PTGER2), gamma-aminobutyric acid receptor subunit alpha(GABRA), gamma-aminobutyric acid type B receptor subunit 1(GABBR1), and 4-aminobutyrate aminotransferase(ABAT). "
3.	Contact Dermatitis (Eczema, Contact) 05/27/2011 - "2-isoprenylhydroquinone-1-glucoside (1), 3,5-dicaffeoylquinic acid (2), and 3,5-dicaffeoylquinic acid methyl ester (3), isolated from Phagnalon rupestre, improved the contact hypersensitivity response to 2,4,6-trinitrochlorobenzene in mice. " 10/01/2007 - "The phenolic compounds isoprenylhydroquinone glucoside (IHG), 3,5-dicaffeoylquinic acid (DCA), and its methyl ester (DCE) have previously been shown to inhibit both contact hypersensitivity (CHS) and peroxynitrite reactivity. "
4.	Osteoporosis 07/25/2023 - "Tubson-2 decoction ameliorates rheumatoid arthritis complicated with osteoporosis in CIA rats involving isochlorogenic acid A regulating IL-17/MAPK pathway."
5.	Rheumatoid Arthritis 07/25/2023 - "Tubson-2 decoction ameliorates rheumatoid arthritis complicated with osteoporosis in CIA rats involving isochlorogenic acid A regulating IL-17/MAPK pathway."

Related Drugs and Biologics

1.	3,5-dicaffeoylquinic acid
2.	3,5-dicaffeoylquinic acid methyl ester
3.	chicoric acid
4.	Chlorogenic Acid
5.	Acids
6.	3,4-di-O-caffeoylquinic acid
7.	5'-O-caffeoylquinic acid
8.	isochlorogenic acid
9.	luteolin-7-glucoside
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration