|1.||Shaik, Shavali: 2 articles (03/2011 - 09/2010)|
|2.||Tseng, Alan: 2 articles (03/2011 - 09/2010)|
|3.||Wei, Wenyi: 2 articles (03/2011 - 09/2010)|
|4.||Inuzuka, Hiroyuki: 2 articles (03/2011 - 09/2010)|
|5.||Wan, Lixin: 2 articles (03/2011 - 09/2010)|
|6.||Zhai, Bo: 2 articles (03/2011 - 09/2010)|
|7.||Gao, Daming: 2 articles (03/2011 - 09/2010)|
|8.||Gygi, Steven P: 2 articles (03/2011 - 09/2010)|
|9.||Zhang, X Z: 1 article (01/2015)|
|10.||Dang, C X: 1 article (01/2015)|
|1.||Parkinson Disease (Parkinson's Disease)
11/20/2009 - "The aim of this study was to develop a new model of sporadic Parkinson disease (PD) based on silencing of the SKP1A gene, a component of the ubiquitin-proteasome/E3 ligase complex, Skp1, Cullin 1, F-box protein, which was found to be highly decreased in the substantia nigra of sporadic PD patients. "
03/01/2009 - "The list included multiple proteins involved in colon cancer pathogenesis: cathepsin B and cathepsin D, cullin 1, Parkinson disease 7, muscle pyruvate kinase, and Ran. "
|2.||Lung Neoplasms (Lung Cancer)
07/19/2013 - "CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells."
07/19/2013 - "In this study, we investigated the expression of CDK-associated Cullin 1 (CAC1) in lung cancer, the effect of CAC1 on the proliferation of human lung cancer A549 cells, and the activation of signaling pathways of mitogen-activated protein kinases (MAPKs). "
09/10/2010 - "These findings indicate that the Rictor/Cullin-1 E3 ligase activity is regulated by a specific signal relay cascade and that misregulation of this mechanism may contribute to the frequent overexpression of SGK1 in various human cancers."
11/15/2011 - "The expression of REST and of an S-phase kinase-associated protein 1/cullin 1/F-box (SCF) protein complex that contains the F-box protein β-transducin repeat-containing protein (β-TRCP) (SCF(β-TRCP) ) in neuroblastoma tumor samples and cell lines was analyzed by immunofluorescence and Western blot analysis. "
|4.||Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
03/03/2011 - "Thus, considerable uncertainty surrounds how FBW7-deficient cells evade cell death in the setting of upregulated Jun, Myc and/or notch 1. Here we show that the E3 ubiquitin ligase SCF(FBW7) (a SKP1-cullin-1-F-box complex that contains FBW7 as the F-box protein) governs cellular apoptosis by targeting MCL1, a pro-survival BCL2 family member, for ubiquitylation and destruction in a manner that depends on phosphorylation by glycogen synthase kinase 3. Human T-ALL cell lines showed a close relationship between FBW7 loss and MCL1 overexpression. "
|5.||Stomach Neoplasms (Stomach Cancer)
|1.||Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
|2.||Proteasome Endopeptidase Complex (Proteasome)
|4.||Mitogen-Activated Protein Kinases
|5.||Connective Tissue Growth Factor
|7.||Activating Transcription Factor 3
|8.||S-Phase Kinase-Associated Proteins (Skp1 Protein)
|9.||Glycogen Synthase Kinase 3
|10.||Nuclear Pore Complex Proteins (Nucleoporins)